PHLPP2 抗体 (C-Term)
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北京 101111
Quick Overview for PHLPP2 抗体 (C-Term) (ABIN8107926)
抗原
See all PHLPP2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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原理
- PHLPP2 Antibody - C-terminal region
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序列
- PVPLSKVFSL EQDPEEAQRV KDQKAIITED NKVNGVTCCT RMLGCTYLYP
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预测反应
- Cow: 100%, Dog: 93%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%
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纯化方法
- Affinity purified
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免疫原
- The immunogen is a synthetic peptide directed towards the C terminal region of human PHLPP2
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anti-PH Domain and Leucine Rich Repeat Protein Phosphatase 2 (PHLPP2) (AA 1295-1323), (C-Term) antibody
PHLPP2 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB15007 unconjugated
anti-PH Domain and Leucine Rich Repeat Protein Phosphatase 2 (PHLPP2) (C-Term) antibodyPHLPP2 适用: 人, 小鼠 WB, ELISA, IHC, IHC (p), IP 宿主: 兔 Polyclonal unconjugated
anti-PH Domain and Leucine Rich Repeat Protein Phosphatase 2 (PHLPP2) (C-Term) antibodyVerified PHLPP2 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-PH Domain and Leucine Rich Repeat Protein Phosphatase 2 (PHLPP2) (AA 4-31), (N-Term) antibodyPHLPP2 适用: 人 WB 宿主: 兔 Polyclonal RB15006 unconjugated
anti-PH Domain and Leucine Rich Repeat Protein Phosphatase 2 (PHLPP2) (C-Term) antibodyPHLPP2 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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说明
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We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP42429-100UG
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.5 mg/mL
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缓冲液
- Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- prevent freeze-thaw cycles
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储存条件
- 4 °C,-20 °C
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储存方法
- For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.
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- PHLPP2 (PH Domain and Leucine Rich Repeat Protein Phosphatase 2 (PHLPP2))
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别名
- PHLPP2
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背景
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Background Information: Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family, specifically acts on 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis. Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation. Inhibits cancer cell proliferation and may act as a tumor suppressor. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Dephosphorylates RAF1 inhibiting its kinase activity.
Gene Name: PH domain and leucine rich repeat protein phosphatase 2
Alternative Symbols: PPM3B, PHLPPL
Protein Name: PH domain leucine-rich repeat-containing protein phosphatase 2
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分子量
- 138 kDa
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基因ID
- 23035
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NCBI登录号
- NP_055835
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UniProt
- Q6ZVD8
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途径
- PI3K-Akt Signaling, Fc-epsilon Receptor Signaling Pathway
抗原
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