Recombinant USP14 抗体
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北京 101111
Quick Overview for Recombinant USP14 抗体 (ABIN8093546)
抗原
See all USP14 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- USP14 Antibody / Ubiquitin carboxyl-terminal hydrolase 14
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纯化方法
- Affinity chromatography
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免疫原
- A synthesized peptide derived from human Ubiquitin carboxyl-terminal hydrolase 14 protein was used as the immunogen for the USP14 antibody.
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亚型
- IgG
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anti-Ubiquitin Specific Peptidase 14 (USP14) (AA 395-494) antibody
USP14 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 6D6 unconjugated
anti-Ubiquitin Specific Peptidase 14 (USP14) (AA 1-30), (N-Term) antibodyUSP14 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB4334 unconjugated
anti-Ubiquitin Specific Peptidase 14 (USP14) (AA 395-494) antibodyUSP14 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 14 (USP14) (AA 1-494) antibodyUSP14 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 14 (USP14) antibodyKD Validated USP14 适用: 人 WB, FACS 宿主: 兔 Monoclonal 24GB2190 unconjugated Recombinant Antibody
anti-Ubiquitin Specific Peptidase 14 (USP14) (AA 355-383), (C-Term) antibodyUSP14 适用: 人 WB 宿主: 兔 Polyclonal RB41691 unconjugated
anti-Ubiquitin Specific Peptidase 14 (USP14) antibodyUSP14 适用: 人 WB, IP 宿主: 兔 Monoclonal unconjugated
anti-Ubiquitin Specific Peptidase 14 (USP14) (AA 1-494) antibodyUSP14 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 14 (USP14) antibodyUSP14 适用: 人, 小鼠, 大鼠 WB 宿主: 小鼠 Monoclonal 9C1 unconjugated
anti-Ubiquitin Specific Peptidase 14 (USP14) (AA 1-494) antibodyUSP14 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the USP14 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the USP14 antibody at -20oC.
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- USP14 (Ubiquitin Specific Peptidase 14 (USP14))
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别名
- USP14
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背景
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USP14 antibody targets Ubiquitin carboxyl-terminal hydrolase 14 (USP14), a deubiquitinating enzyme that regulates protein turnover by removing ubiquitin chains from substrates prior to proteasomal degradation. USP14 localizes predominantly to the cytoplasm and is tightly associated with the 26S proteasome, where it modulates proteasome activity and substrate processing. As a member of the ubiquitin-specific protease family, USP14 plays a critical role in maintaining protein homeostasis by fine-tuning ubiquitin-dependent degradation pathways. Its proteasome-associated function positions USP14 as an important checkpoint in cellular protein quality control.
Functionally, USP14 acts as a regulator of proteasomal degradation by trimming ubiquitin chains from proteins as they engage the proteasome. This activity can delay or alter substrate degradation, allowing cells to control the timing and extent of protein turnover. Through this mechanism, USP14 influences diverse cellular processes including signal transduction, cell cycle regulation, and stress responses. Because ubiquitination governs the stability of many regulatory proteins, USP14 contributes to the dynamic balance between protein synthesis and degradation. A USP14 antibody supports studies examining ubiquitin signaling and proteasome-mediated proteolysis.
USP14 expression is broadly observed across tissues, reflecting the universal requirement for regulated protein degradation in eukaryotic cells. Its activity is particularly relevant in cells with high proteasome demand, such as neurons and rapidly dividing cells. Analysis of USP14 localization and abundance provides insight into how cells adapt proteasomal function under conditions of proteotoxic stress or altered metabolic state. Changes in USP14 activity can influence the accumulation or clearance of ubiquitinated proteins, impacting overall cellular homeostasis.
From a biological and disease-relevance perspective, USP14 has been studied extensively in neurobiology and cancer research. Dysregulation of proteasome-associated deubiquitination has been linked to neurodegenerative disorders characterized by protein aggregation, as well as to altered signaling pathways in cancer. USP14 activity can modulate the degradation of key regulatory proteins, making it an important factor in disease-associated changes in protein stability. Understanding USP14 regulation contributes to broader investigations of ubiquitin-proteasome system function in health and disease.
At the molecular level, USP14 is encoded by the USP14 gene and produces a protein of approximately 56 kDa. The enzyme contains a conserved catalytic domain required for ubiquitin cleavage and regulatory regions that mediate interaction with the proteasome. USP14 activity is influenced by proteasome binding and cellular signaling context. A USP14 antibody supports research applications focused on ubiquitin biology, proteasome regulation, and protein degradation pathways, with NSJ Bioreagents providing reagents intended for research use. -
UniProt
- P54578
抗原
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