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USP14 抗体 (C-Term)

USP14 适用: 人 WB 宿主: 兔 Polyclonal RB41691 unconjugated
产品编号 ABIN1881985
发货至: 中国
  • 抗原 See all USP14 抗体
    USP14 (Ubiquitin Specific Peptidase 14 (USP14))
    抗原表位
    • 12
    • 11
    • 8
    • 8
    • 5
    • 2
    • 2
    • 1
    AA 355-383, C-Term
    适用
    • 64
    • 9
    • 8
    • 5
    • 2
    • 1
    宿主
    • 54
    • 9
    克隆类型
    • 48
    • 16
    多克隆
    标记
    • 32
    • 5
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This USP14 antibody is un-conjugated
    应用范围
    • 46
    • 29
    • 13
    • 8
    • 7
    • 6
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    预测反应
    B, M
    纯化方法
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    免疫原
    This USP14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 355-383 amino acids from the C-terminal region of human USP14.
    克隆位点
    RB41691
    亚型
    Ig Fraction
    Top Product
    Discover our top product USP14 Primary Antibody
  • 应用备注
    WB: 1:1000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    有效期
    6 months
  • Hyrskyluoto, Bruelle, Lundh, Do, Kivinen, Rappou, Reijonen, Waltimo, Petersén, Lindholm, Korhonen: "Ubiquitin-specific protease-14 reduces cellular aggregates and protects against mutant huntingtin-induced cell degeneration: involvement of the proteasome and ER stress-activated kinase IRE1?." in: Human molecular genetics, Vol. 23, Issue 22, pp. 5928-39, (2014) (PubMed).

    Davila, Froeling, Tan, Bonnard, Boland, Snippe, Hibberd, Seielstad: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, (2010) (PubMed).

    Chen, Qin, Li, Walters, Wilson, Mei, Wilson: "The proteasome-associated deubiquitinating enzyme Usp14 is essential for the maintenance of synaptic ubiquitin levels and the development of neuromuscular junctions." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 29, Issue 35, pp. 10909-19, (2009) (PubMed).

    Nagai, Kadowaki, Maruyama, Takeda, Nishitoh, Ichijo: "USP14 inhibits ER-associated degradation via interaction with IRE1alpha." in: Biochemical and biophysical research communications, Vol. 379, Issue 4, pp. 995-1000, (2009) (PubMed).

    Mines, Goodwin, Limbird, Cui, Fan: "Deubiquitination of CXCR4 by USP14 is critical for both CXCL12-induced CXCR4 degradation and chemotaxis but not ERK ativation." in: The Journal of biological chemistry, Vol. 284, Issue 9, pp. 5742-52, (2009) (PubMed).

    Koulich, Li, DeMartino: "Relative structural and functional roles of multiple deubiquitylating proteins associated with mammalian 26S proteasome." in: Molecular biology of the cell, Vol. 19, Issue 3, pp. 1072-82, (2008) (PubMed).

  • 抗原
    USP14 (Ubiquitin Specific Peptidase 14 (USP14))
    别名
    USP14 (USP14 产品)
    别名
    TGT antibody, DDBDRAFT_0202821 antibody, DDBDRAFT_0237695 antibody, DDB_0202821 antibody, DDB_0237695 antibody, 2610005K12Rik antibody, 2610037B11Rik antibody, AW107924 antibody, C78769 antibody, ax antibody, zgc:55949 antibody, wu:fk63d09 antibody, MGC81945 antibody, tgt antibody, MGC69343 antibody, USP14 antibody, ubiquitin specific peptidase 14 antibody, peptidase C19 family protein antibody, ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) antibody, ubiquitin specific protease 14 antibody, ubiquitin specific peptidase 14 S homeolog antibody, universal stress protein antibody, Ubiquitin carboxyl-terminal hydrolase 14 antibody, USP14 antibody, usp14 antibody, Usp14 antibody, Bm1_28765 antibody, usp14.S antibody, RR_RS06480 antibody, usp-14 antibody
    背景
    This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
    分子量
    56069
    NCBI登录号
    NP_001032411, NP_005142
    UniProt
    P54578
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