UCHL3 抗体 (C-Term)
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Quick Overview for UCHL3 抗体 (C-Term) (ABIN8093545)
抗原
See all UCHL3 (Uchl3) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-223, C-Term
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原理
- UCHL3 Antibody / Ubiquitin C-terminal hydrolase L3
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human UCHL3 recombinant protein (amino acids M1-N223) was used as the immunogen for the Ubiquitin C-terminal hydrolase L3 antibody.
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亚型
- IgG
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anti-Ubiquitin Carboxyl-terminal Esterase L3 (Ubiquitin Thiolesterase) (Uchl3) (AA 195-225), (C-Term) antibody
Uchl3 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB4187 unconjugated
anti-Ubiquitin Carboxyl-terminal Esterase L3 (Ubiquitin Thiolesterase) (Uchl3) (AA 131-230) antibodyUchl3 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4E9 unconjugated
anti-Ubiquitin Carboxyl-terminal Esterase L3 (Ubiquitin Thiolesterase) (Uchl3) (AA 195-225) antibodyUchl3 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Carboxyl-terminal Esterase L3 (Ubiquitin Thiolesterase) (Uchl3) antibodyUchl3 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Ubiquitin Carboxyl-terminal Esterase L3 (Ubiquitin Thiolesterase) (Uchl3) (AA 1-220) antibodyUchl3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Carboxyl-terminal Esterase L3 (Ubiquitin Thiolesterase) (Uchl3) (N-Term) antibodyUchl3 适用: 人, 大鼠, 小鼠, Cow, 马, 犬, 兔, 豚鼠, 斑马鱼, Pig, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Carboxyl-terminal Esterase L3 (Ubiquitin Thiolesterase) (Uchl3) (Internal Region) antibodyUchl3 适用: 人, 大鼠, 小鼠, 犬, 小鸡 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Carboxyl-terminal Esterase L3 (Ubiquitin Thiolesterase) (Uchl3) (AA 1-220) antibodyUchl3 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Carboxyl-terminal Esterase L3 (Ubiquitin Thiolesterase) (Uchl3) antibodyUchl3 适用: 人 WB, FACS 宿主: 兔 Monoclonal 24GB1770 unconjugated Recombinant Antibody
anti-Ubiquitin Carboxyl-terminal Esterase L3 (Ubiquitin Thiolesterase) (Uchl3) antibodyUchl3 适用: 人 WB, FACS 宿主: 兔 Monoclonal 24GB1975 unconjugated Recombinant Antibody
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应用备注
- Optimal dilution of the Ubiquitin C-terminal hydrolase L3 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the Ubiquitin C-terminal hydrolase L3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- UCHL3 (Uchl3) (Ubiquitin Carboxyl-terminal Esterase L3 (Ubiquitin Thiolesterase) (Uchl3))
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别名
- UCHL3
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背景
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Ubiquitin C-terminal hydrolase L3 antibody targets Ubiquitin C-terminal hydrolase L3, encoded by the UCHL3 gene. Ubiquitin C-terminal hydrolase L3 is an intracellular deubiquitinating enzyme that catalyzes the cleavage of ubiquitin from the C-terminus of ubiquitin-conjugated substrates. As a member of the ubiquitin C-terminal hydrolase family, it plays a fundamental role in regulating ubiquitin-dependent protein modification and turnover.
Unlike substrate-specific ubiquitin ligases, Ubiquitin C-terminal hydrolase L3 functions as a broad regulator of ubiquitin recycling. By regenerating free ubiquitin from conjugated or precursor forms, it sustains the availability of ubiquitin required for continuous proteasomal degradation and signaling regulation. A Ubiquitin C-terminal hydrolase L3 antibody supports studies examining deubiquitination dynamics and maintenance of ubiquitin homeostasis within the cell.
Ubiquitin C-terminal hydrolase L3 is primarily localized to the cytoplasm, where it interfaces with ubiquitinated proteins involved in signaling cascades, metabolic control, and stress response pathways. Its widespread expression across cell types reflects a housekeeping role that supports core cellular functions rather than tissue-restricted specialization. Modulation of UCHL3 activity can therefore influence multiple pathways simultaneously through indirect effects on ubiquitin availability.
From a biological and disease-related perspective, altered regulation of Ubiquitin C-terminal hydrolase L3 has been investigated in cancer and models of cellular stress, where imbalance between ubiquitination and deubiquitination contributes to abnormal protein stabilization or degradation. Changes in UCHL3 expression or activity may impact cell cycle progression, survival signaling, and proteotoxic stress tolerance, making it a relevant target in studies of ubiquitin system dysregulation.
At the molecular level, Ubiquitin C-terminal hydrolase L3 contains a conserved thiol protease catalytic domain characteristic of UCH family enzymes. Its apparent activity in biochemical assays can vary depending on substrate context and cellular conditions rather than changes in protein size or sequence. Ubiquitin C-terminal hydrolase L3 antibody reagents enable investigation of deubiquitination pathways and ubiquitin system regulation, with NSJ Bioreagents providing reagents intended for research use. -
UniProt
- P15374
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途径
- Feeding Behaviour, Positive Regulation of fat Cell Differentiation
抗原
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