TFPI2 抗体 (AA 100-235)
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北京 101111
Quick Overview for TFPI2 抗体 (AA 100-235) (ABIN8093520)
抗原
See all TFPI2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 100-235
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原理
- TFPI2 Antibody / Tissue factor pathway inhibitor 2
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免疫原
- A recombinant fragment (around amino acids 100-235) of human TFPI2 protein (exact sequence is proprietary) was used as the immunogen for the Placental Protein 5/TFPI2 antibody.
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亚型
- IgG2, kappa
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anti-Tissue Factor Pathway Inhibitor 2 (TFPI2) (AA 1-235) antibody
TFPI2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Tissue Factor Pathway Inhibitor 2 (TFPI2) (AA 135-235) antibodyTFPI2 适用: 人 IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Tissue Factor Pathway Inhibitor 2 (TFPI2) antibodyTFPI2 适用: 人, 小鼠, 大鼠 WB, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Tissue Factor Pathway Inhibitor 2 (TFPI2) (AA 23-235) antibodyTFPI2 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Tissue Factor Pathway Inhibitor 2 (TFPI2) (AA 23-235) antibodyTFPI2 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Tissue Factor Pathway Inhibitor 2 (TFPI2) (AA 1-235) antibodyTFPI2 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3E8 unconjugated
anti-Tissue Factor Pathway Inhibitor 2 (TFPI2) (N-Term) antibodyTFPI2 适用: 人, 小鼠 WB, IHC, ICC, FACS, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Tissue Factor Pathway Inhibitor 2 (TFPI2) (AA 23-235) antibodyTFPI2 适用: 人 IHC 宿主: 兔 Polyclonal unconjugated
anti-Tissue Factor Pathway Inhibitor 2 (TFPI2) (AA 72-121) antibodyTFPI2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Tissue Factor Pathway Inhibitor 2 (TFPI2) (AA 21-70) antibodyTFPI2 适用: 人, Cow, 犬, 豚鼠, Pig WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the Placental Protein 5/TFPI2 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.05 % BSA, 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Placental Protein 5/TFPI2 antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.
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- TFPI2 (Tissue Factor Pathway Inhibitor 2 (TFPI2))
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别名
- TFPI2
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背景
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Placental Protein 5 antibody, also known as TFPI2 antibody, recognizes Placental Protein 5, the historical name for Tissue factor pathway inhibitor 2 encoded by the TFPI2 gene. Originally identified in placental tissue, Placental Protein 5 is a secreted Kunitz-type serine protease inhibitor that associates with the extracellular matrix and regulates pericellular proteolysis. The protein contains three tandem Kunitz domains that enable inhibition of multiple serine proteases involved in matrix degradation and tissue remodeling. Placental Protein 5 antibody is widely used in research examining extracellular matrix regulation, trophoblastic biology, and tumor invasion mechanisms.
TFPI2 is synthesized with a signal peptide and secreted into the extracellular environment, where it binds matrix components and modulates local protease activity. Although structurally related to Tissue factor pathway inhibitor 1, Placental Protein 5 primarily functions in extracellular matrix homeostasis rather than directly regulating the tissue factor coagulation cascade. By inhibiting proteases such as plasmin and trypsin-like enzymes, TFPI2 contributes to maintaining tissue integrity and limiting excessive matrix breakdown. Reduced TFPI2 expression has been reported in various malignancies, often associated with promoter hypermethylation and increased invasive potential.
Expression of Placental Protein 5 has been documented in placenta, vascular endothelium, and selected epithelial tissues. In placental tissue, extracellular and pericellular localization patterns are consistent with its matrix-associated inhibitory role. In cancer biology studies, TFPI2 antibody is frequently used to evaluate epigenetic silencing, stromal interactions, and tumor microenvironment remodeling. Clone TFPI2/13028 is designed to detect Placental Protein 5 in research applications and supports investigation of extracellular protease regulation and matrix-associated signaling pathways. -
UniProt
- P48307
抗原
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