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TEK 抗体 (AA 700-1000)

Name: TEK 抗体 (AA 700-1000)
SKU: ABIN8093513
Availability: OutOfStock

The 小鼠单克隆 anti-TEK antibody is suitable to detect TEK in samples from 人. It has been validated for IHC.

产品编号 ABIN8093513

发货至: 中国

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Quick Overview for TEK 抗体 (AA 700-1000) (ABIN8093513)

抗原

See all TEK 抗体

TEK (TEK Tyrosine Kinase, Endothelial (TEK))

适用

人

宿主

小鼠

克隆类型

单克隆

标记

This TEK antibody is un-conjugated

应用范围

Immunohistochemistry (IHC)

克隆位点

TEK-9412

Discover our top product TEK Primary Antibody

抗原表位
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2

1

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1
AA 700-1000

原理

TIE2 Antibody / TEK

免疫原

A recombinant fragment (around amino acids 700-1000) of human TEK protein (exact sequence is proprietary) was used as the immunogen for the Angiopoietin Receptor/TIE2 antibody.

亚型

IgG1, kappa
anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 66-185) antibody
TEK 适用: 人 WB 宿主: 小鼠 Monoclonal 3A5 unconjugated

anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 23-616) antibody
TEK 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, FACS, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 571-748) antibody
TEK 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 3F5B9 unconjugated

anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 758-789) antibody
TEK 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 758-789), (C-Term) antibody
TEK 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB01525-01526 unconjugated

anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 701-800) antibody
TEK 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3F8 unconjugated

anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 401-550) antibody
TEK 适用: 人 FACS, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 500-750) antibody
TEK 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-TEK Tyrosine Kinase, Endothelial (TEK) (pTyr992) antibody
TEK 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 286-465) antibody
TEK 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

应用备注

Optimal dilution of the Angiopoietin Receptor/TIE2 antibody should be determined by the researcher.

限制

仅限研究用
状态

Liquid

浓度

0.2 mg/mL

缓冲液

0.2 mg/mL in 1X PBS with 0.05 % BSA, 0.05 % sodium azide

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C,-80 °C

储存方法

Angiopoietin Receptor/TIE2 antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.
抗原

TEK (TEK Tyrosine Kinase, Endothelial (TEK))

别名

TIE2

背景

Angiopoietin Receptor antibody, also known as TIE2 antibody, recognizes a receptor tyrosine kinase encoded by the TEK gene. This protein is commonly referred to as TIE2, TEK receptor tyrosine kinase, CD202b, and Tunica interna endothelial cell kinase in the literature. TIE2 is a transmembrane receptor primarily expressed in vascular endothelial cells, where it regulates angiogenesis, vascular remodeling, and endothelial cell survival.

TIE2 belongs to the receptor tyrosine kinase family and contains extracellular immunoglobulin-like domains, epidermal growth factor-like repeats, fibronectin type III domains, a single transmembrane region, and an intracellular tyrosine kinase domain. Binding of its ligands, Angiopoietin-1 and Angiopoietin-2, induces receptor dimerization and autophosphorylation, leading to activation of downstream pathways including PI3K-AKT and MAPK signaling. These cascades promote endothelial quiescence, vessel maturation, and maintenance of vascular integrity.

During embryogenesis, TIE2 signaling is essential for vascular network formation and stabilization. In adult tissues, it maintains endothelial barrier function and regulates vascular permeability. Dysregulated Angiopoietin-TIE2 signaling contributes to tumor angiogenesis, inflammatory disorders, diabetic retinopathy, and vascular malformations. Activating mutations in the TEK gene have been linked to inherited venous malformations, emphasizing the receptorâ€™s importance in vascular biology.

TIE2 is predominantly localized to the plasma membrane of endothelial cells, with activated receptor complexes undergoing internalization and cytoplasmic signaling. Because of its endothelial-restricted expression profile, Angiopoietin Receptor antibody is widely used in research applications to evaluate vascular structures and angiogenic signaling pathways. An Angiopoietin Receptor antibody can be used to detect TIE2 expression in endothelial biology and tumor angiogenesis research.

UniProt

Q02763

途径

RTK signaling, Growth Factor Binding