TEK 抗体 (AA 700-1000)
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北京 101111
Quick Overview for TEK 抗体 (AA 700-1000) (ABIN8093512)
抗原
See all TEK 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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抗原表位
- AA 700-1000
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原理
- TIE2 Antibody / TEK (azide and preservative free)
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免疫原
- A recombinant fragment (around amino acids 700-1000) of human TEK protein (exact sequence is proprietary) was used as the immunogen for the CD202b/TIE2 antibody.
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亚型
- IgG1, kappa
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anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 66-185) antibody
TEK 适用: 人 WB 宿主: 小鼠 Monoclonal 3A5 unconjugated
anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 23-616) antibodyTEK 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, FACS, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 571-748) antibodyTEK 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 3F5B9 unconjugated
anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 758-789) antibodyTEK 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 758-789), (C-Term) antibodyTEK 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB01525-01526 unconjugated
anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 701-800) antibodyTEK 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3F8 unconjugated
anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 401-550) antibodyTEK 适用: 人 FACS, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 500-750) antibodyTEK 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-TEK Tyrosine Kinase, Endothelial (TEK) (pTyr992) antibodyTEK 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 286-465) antibodyTEK 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the CD202b/TIE2 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- CD202b/TIE2 antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.
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- TEK (TEK Tyrosine Kinase, Endothelial (TEK))
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别名
- TIE2
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背景
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CD202b antibody, also known as TIE2 antibody, recognizes a receptor tyrosine kinase encoded by the TEK gene. This protein is widely referred to as TIE2, TEK receptor tyrosine kinase, and Tunica interna endothelial cell kinase in the literature. CD202b is predominantly expressed on vascular endothelial cells, where it plays a critical role in angiogenesis, vascular maturation, and endothelial cell survival.
CD202b belongs to the receptor tyrosine kinase family and contains multiple extracellular immunoglobulin-like domains, epidermal growth factor-like repeats, fibronectin type III domains, a single transmembrane region, and an intracellular kinase domain. Upon binding its ligands, Angiopoietin-1 and Angiopoietin-2, CD202b undergoes dimerization and autophosphorylation, activating downstream signaling pathways including PI3K-AKT and MAPK. These signaling cascades regulate endothelial quiescence, vascular permeability, and vessel stabilization.
During embryonic development, CD202b signaling is essential for blood vessel formation and remodeling. In adult tissues, it maintains endothelial integrity and supports vascular homeostasis. Dysregulation of TIE2 signaling contributes to pathological angiogenesis observed in solid tumors, inflammatory diseases, and retinal vascular disorders. Activating mutations in the TEK gene have been identified in inherited venous malformations, further emphasizing its importance in vascular biology.
CD202b is primarily localized to the plasma membrane of endothelial cells, with activated receptor complexes undergoing internalization and cytoplasmic signaling. Because of its endothelial-restricted expression profile, CD202b antibody is commonly used in research applications to evaluate vascular structures and angiogenic signaling pathways. A CD202b antibody can be used to detect TIE2 expression in endothelial biology, cancer research, and angiogenesis studies. -
UniProt
- Q02763
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途径
- RTK signaling, Growth Factor Binding
抗原
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