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TEK 抗体 (AA 700-1000)

Name: TEK 抗体 (AA 700-1000)
SKU: ABIN8093511
Availability: OutOfStock

The 小鼠单克隆 anti-TEK antibody (Clone TEK-9411) (ABIN8093511) specifically detects TEK in IHC. The antibody is reactive with 人 samples.

产品编号 ABIN8093511

发货至: 中国

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中国
北京 101111

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Quick Overview for TEK 抗体 (AA 700-1000) (ABIN8093511)

抗原

See all TEK 抗体

TEK (TEK Tyrosine Kinase, Endothelial (TEK))

适用

人

宿主

小鼠

克隆类型

单克隆

标记

This TEK antibody is un-conjugated

应用范围

Immunohistochemistry (IHC)

克隆位点

TEK-9411

Discover our top product TEK Primary Antibody

抗原表位
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2

1

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1

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1

1
AA 700-1000

原理

TIE2 Antibody / TEK

免疫原

A recombinant fragment (around amino acids 700-1000) of human TEK protein (exact sequence is proprietary) was used as the immunogen for the CD202b/TIE2 antibody.

亚型

IgG1, kappa
anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 66-185) antibody
TEK 适用: 人 WB 宿主: 小鼠 Monoclonal 3A5 unconjugated

anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 23-616) antibody
TEK 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, FACS, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 571-748) antibody
TEK 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 3F5B9 unconjugated

anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 758-789) antibody
TEK 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 758-789), (C-Term) antibody
TEK 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB01525-01526 unconjugated

anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 701-800) antibody
TEK 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3F8 unconjugated

anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 401-550) antibody
TEK 适用: 人 FACS, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 500-750) antibody
TEK 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-TEK Tyrosine Kinase, Endothelial (TEK) (pTyr992) antibody
TEK 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 286-465) antibody
TEK 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

应用备注

Optimal dilution of the CD202b/TIE2 antibody should be determined by the researcher.

限制

仅限研究用
状态

Liquid

浓度

0.2 mg/mL

缓冲液

0.2 mg/mL in 1X PBS with 0.05 % BSA, 0.05 % sodium azide

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C,-80 °C

储存方法

CD202b/TIE2 antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.
抗原

TEK (TEK Tyrosine Kinase, Endothelial (TEK))

别名

TIE2

背景

CD202b antibody, also known as TIE2 antibody, recognizes a receptor tyrosine kinase encoded by the TEK gene. This protein is widely referred to as TIE2, TEK receptor tyrosine kinase, and Tunica interna endothelial cell kinase in the literature. CD202b is predominantly expressed on vascular endothelial cells, where it plays a critical role in angiogenesis, vascular maturation, and endothelial cell survival.

CD202b belongs to the receptor tyrosine kinase family and contains multiple extracellular immunoglobulin-like domains, epidermal growth factor-like repeats, fibronectin type III domains, a single transmembrane region, and an intracellular kinase domain. Upon binding its ligands, Angiopoietin-1 and Angiopoietin-2, CD202b undergoes dimerization and autophosphorylation, activating downstream signaling pathways including PI3K-AKT and MAPK. These signaling cascades regulate endothelial quiescence, vascular permeability, and vessel stabilization.

During embryonic development, CD202b signaling is essential for blood vessel formation and remodeling. In adult tissues, it maintains endothelial integrity and supports vascular homeostasis. Dysregulation of TIE2 signaling contributes to pathological angiogenesis observed in solid tumors, inflammatory diseases, and retinal vascular disorders. Activating mutations in the TEK gene have been identified in inherited venous malformations, further emphasizing its importance in vascular biology.

CD202b is primarily localized to the plasma membrane of endothelial cells, with activated receptor complexes undergoing internalization and cytoplasmic signaling. Because of its endothelial-restricted expression profile, CD202b antibody is commonly used in research applications to evaluate vascular structures and angiogenic signaling pathways. A CD202b antibody can be used to detect TIE2 expression in endothelial biology, cancer research, and angiogenesis studies.

UniProt

Q02763

途径

RTK signaling, Growth Factor Binding