Recombinant SOX10 抗体 (AA 115-269)
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北京 101111
Quick Overview for Recombinant SOX10 抗体 (AA 115-269) (ABIN8093491)
抗原
See all SOX10 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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抗原表位
- AA 115-269
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原理
- SOX10 Antibody / SRY-box transcription factor 10 (azide and preservative free)
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免疫原
- Recombinant human SOX10 protein fragment (around amino acids 115-269) (exact sequence is proprietary) was used as the immunogen for the SRY-box transcription factor 10/SOX10 antibody.
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亚型
- IgG2b, kappa
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anti-SRY (Sex Determining Region Y)-Box 10 (SOX10) (AA 115-269) antibody
SOX10 适用: 人, 小鼠 WB, IHC 宿主: 小鼠 Monoclonal SOX10-991 unconjugated
anti-SRY (Sex Determining Region Y)-Box 10 (SOX10) (AA 231-259) antibodySOX10 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB21835 unconjugated
anti-SRY (Sex Determining Region Y)-Box 10 (SOX10) (Middle Region) antibodySOX10 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-SRY (Sex Determining Region Y)-Box 10 (SOX10) (AA 147-252) antibodySOX10 适用: 人 IHC, ELISA 宿主: 小鼠 Monoclonal 2E7E8 unconjugated
anti-SRY (Sex Determining Region Y)-Box 10 (SOX10) (AA 147-252) antibodySOX10 适用: 人 FACS, ELISA 宿主: 小鼠 Monoclonal 2E7B5 unconjugated
anti-SRY (Sex Determining Region Y)-Box 10 (SOX10) (AA 115-269) antibodySOX10 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal SOX10-992 unconjugated
anti-SRY (Sex Determining Region Y)-Box 10 (SOX10) (AA 115-269) antibodySOX10 适用: 人, 小鼠 WB, IHC 宿主: 小鼠 Monoclonal rSOX10-1074 unconjugated Recombinant Antibody
anti-SRY (Sex Determining Region Y)-Box 10 (SOX10) (AA 115-269) antibodySOX10 适用: 人, 小鼠 WB, IHC 宿主: 兔 Monoclonal SOX10-2311R unconjugated Recombinant Antibody
anti-SRY (Sex Determining Region Y)-Box 10 (SOX10) (AA 200-300) antibodySOX10 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-SRY (Sex Determining Region Y)-Box 10 (SOX10) antibodySOX10 适用: 人 WB, IHC, IF, ELISA 宿主: 兔 Monoclonal 8E1 unconjugated Recombinant Antibody
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应用备注
- Optimal dilution of the SRY-box transcription factor 10/SOX10 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- SRY-box transcription factor 10/SOX10 antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.
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- SOX10 (SRY (Sex Determining Region Y)-Box 10 (SOX10))
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别名
- SOX10
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背景
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SRY-box transcription factor 10 Antibody recognizes SOX10, a nuclear DNA-binding protein encoded by the SOX10 gene and belonging to the SOX family of high mobility group box transcription factors. SOX10 contains a conserved HMG-box domain that enables sequence-specific DNA binding and transcriptional activation of genes essential for neural crest development and lineage specification. This transcription factor localizes predominantly to the nucleus, consistent with its regulatory role in gene expression programs controlling cell fate determination.
SOX10 plays a critical role during embryogenesis, where it regulates neural crest cell survival, migration, and differentiation. It is indispensable for formation of melanocytes, Schwann cells, peripheral glial cells, and elements of the enteric nervous system. In melanocyte biology, SOX10 functions upstream of MITF and influences pigmentation pathways by regulating genes involved in melanin synthesis and melanocyte maintenance. In peripheral nerve development, SOX10 contributes to Schwann cell maturation and myelination through interaction with signaling pathways including Wnt, Notch, and neuregulin-mediated mechanisms.
In adult tissues, SOX10 expression is largely restricted to melanocytes within the basal epidermis and hair follicles and to Schwann cells associated with peripheral nerves. This lineage-restricted distribution makes SOX10 antibody a valuable marker for identifying neural crest-derived cell populations. Nuclear staining is characteristic of SOX10 detection and reflects its function as a transcription factor.
SOX10 has significant relevance in oncology research. Expression is frequently observed in melanoma, malignant peripheral nerve sheath tumors, and clear cell sarcoma, where nuclear staining supports identification of melanocytic or neural crest differentiation. SOX10 expression has also been reported in subsets of triple-negative breast carcinoma and salivary gland tumors exhibiting basal-like or myoepithelial characteristics. Dysregulated SOX10 activity may contribute to tumor progression and cellular plasticity in melanoma and related malignancies.
SRY-box transcription factor 10 Antibody / SOX10 (clone rSOX10/13506) is a recombinant monoclonal antibody suitable for detecting SOX10 protein expression in research applications focused on neural crest biology, melanocyte differentiation, peripheral nerve studies, and tumor characterization. -
UniProt
- P56693
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途径
- Chromatin Binding
抗原
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