Recombinant SOS1 抗体
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Quick Overview for Recombinant SOS1 抗体 (ABIN8093487)
抗原
See all SOS1 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- SOS1 Antibody / Son of sevenless 1
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纯化方法
- Affinity purification
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免疫原
- A synthetic peptide derived from human SOS1 protein was used as the immunogen for the Son of Sevenless 1 / SOS1 antibody.
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亚型
- IgG1
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anti-Son of Sevenless Homolog 1 (SOS1) (AA 1140-1281) antibody
SOS1 适用: 人 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Son of Sevenless Homolog 1 (SOS1) (AA 313-420) antibodySOS1 适用: 人 ELISA, PLA 宿主: 小鼠 Monoclonal 4C1 unconjugated
anti-Son of Sevenless Homolog 1 (SOS1) antibodySOS1 适用: 人, 小鼠 WB, ELISA, IF 宿主: 小鼠 Monoclonal SOS-01 unconjugated
anti-Son of Sevenless Homolog 1 (SOS1) antibodySOS1 适用: 人, 小鼠 WB, IF, EIA 宿主: 小鼠 Monoclonal SOS-1 unconjugated
anti-Son of Sevenless Homolog 1 (SOS1) (AA 934-962) antibodySOS1 适用: 人 WB 宿主: 兔 Polyclonal RB23356 unconjugated
anti-Son of Sevenless Homolog 1 (SOS1) (AA 1034-1333) antibodySOS1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Son of Sevenless Homolog 1 (SOS1) (AA 353-402) antibodySOS1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Son of Sevenless Homolog 1 (SOS1) (AA 313-420) antibodySOS1 适用: 人 ELISA, WB 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- Optimal dilution of the Son of Sevenless 1 / SOS1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in stabilizing components, phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles
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储存条件
- 4 °C,-20 °C
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储存方法
- Store the Son of Sevenless 1 / SOS1 antibody at -20oC for one year from date of receipt. After reconstitution, at 4oC for one month. It can also be aliquoted and stored frozen at -20oC for six months. Avoid repeated freeze-thaw cycles.
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- SOS1 (Son of Sevenless Homolog 1 (SOS1))
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别名
- SOS1
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背景
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Son of Sevenless 1 (SOS1) is a cytoplasmic signaling protein encoded by the human SOS1 gene and functions as a Ras guanine nucleotide exchange factor that activates Ras proteins during growth factor receptor signaling. Son of Sevenless 1 Antibody / SOS1 (clone ABBE-19) targets this critical Ras pathway regulator that mediates GDP-GTP exchange on Ras proteins, enabling downstream signaling through the MAPK and ERK pathways. SOS1 belongs to the Son of Sevenless family of Ras activators and is widely expressed in many tissues where it participates in receptor tyrosine kinase signaling and cellular proliferation pathways.
SOS1 antibody, also referred to as Son of Sevenless homolog 1 antibody in the literature, recognizes a signaling protein that serves as a central mediator linking activated receptor complexes to Ras activation. SOS1 interacts with adaptor proteins such as GRB2 following activation of receptors including EGFR and other receptor tyrosine kinases. This interaction recruits SOS1 to the plasma membrane where it promotes the exchange of GDP for GTP on Ras, converting Ras into its active signaling state. Through this mechanism, SOS1 plays an essential role in transmitting extracellular growth signals to intracellular kinase cascades.
The SOS1 protein contains multiple functional domains that regulate Ras activation and membrane recruitment. These include a Dbl homology domain and pleckstrin homology domain involved in membrane association, a Ras exchanger motif responsible for catalytic nucleotide exchange, and proline-rich regions that mediate binding to SH3 domain-containing adaptor proteins. Structural studies have demonstrated that SOS1 adopts an autoinhibited conformation that becomes activated upon membrane recruitment and interaction with Ras-GTP, creating a positive feedback mechanism that amplifies Ras signaling.
SOS1 functions within the Ras-MAPK signaling pathway, a fundamental regulatory system controlling cell growth, differentiation, and survival. Dysregulation of Ras signaling can lead to abnormal cellular proliferation and is strongly associated with oncogenic transformation. Alterations in SOS1 activity have been implicated in developmental disorders such as Noonan syndrome as well as in multiple cancer types where Ras signaling pathways are aberrantly activated.
In addition to its role in growth factor signaling, SOS1 contributes to broader cellular signaling networks that regulate cytoskeletal organization and cell migration. The protein can interact with multiple adaptor proteins and signaling complexes, allowing it to integrate signals from different receptor pathways. These interactions position SOS1 as an important hub in cellular signaling networks controlling proliferation and differentiation.
A recombinant rabbit monoclonal clone ABBE-19 antibody targets SOS1 and can be used to investigate Ras pathway signaling, receptor tyrosine kinase activation, and downstream MAPK signaling mechanisms. Detection of SOS1 expression is valuable for studying signaling networks involved in cell growth, oncogenic transformation, and developmental signaling pathways. -
UniProt
- P01106
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途径
- RTK signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Hepatitis C, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling
抗原
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