PDE4A 抗体 (N-Term)
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Quick Overview for PDE4A 抗体 (N-Term) (ABIN8093407)
抗原
See all PDE4A 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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原理
- PDE4A Antibody / cAMP-specific 3,5-cyclic phosphodiesterase 4A
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纯化方法
- Immunogen affinity purified
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免疫原
- A synthetic peptide corresponding to a sequence at the N-terminus of human Phosphodiesterase 4A was used as the immunogen for the PDE4A antibody.
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亚型
- IgG
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anti-phosphodiesterase 4A, CAMP-Specific (PDE4A) antibody
PDE4A 适用: 人 WB, IHC, IF, FACS, IHC (p) 宿主: 小鼠 Monoclonal 5C6 unconjugated
anti-phosphodiesterase 4A, CAMP-Specific (PDE4A) antibodyPDE4A 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-phosphodiesterase 4A, CAMP-Specific (PDE4A) antibodyPDE4A 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-phosphodiesterase 4A, CAMP-Specific (PDE4A) (C-Term) antibodyPDE4A 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-phosphodiesterase 4A, CAMP-Specific (PDE4A) (AA 32-61), (N-Term) antibodyPDE4A 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB36661 unconjugated
anti-phosphodiesterase 4A, CAMP-Specific (PDE4A) (AA 1-647) antibodyPDE4A 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-phosphodiesterase 4A, CAMP-Specific (PDE4A) (AA 1-647) antibodyPDE4A 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- Optimal dilution of the PDE4A antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the PDE4A antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- PDE4A (phosphodiesterase 4A, CAMP-Specific (PDE4A))
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别名
- PDE4A
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背景
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PDE4A antibody targets Phosphodiesterase 4A, encoded by the PDE4A gene. Phosphodiesterase 4A is a member of the phosphodiesterase 4 family of enzymes that specifically hydrolyze cyclic adenosine monophosphate (cAMP), a key second messenger involved in intracellular signaling. PDE4A is predominantly localized to the cytoplasm and associates with signaling complexes that spatially restrict cAMP degradation within cells.
Functionally, Phosphodiesterase 4A regulates the amplitude and duration of cAMP-dependent signaling pathways by controlling intracellular cAMP concentrations. Through this activity, PDE4A influences protein kinase A activation and downstream transcriptional and metabolic responses. A PDE4A antibody supports studies focused on cAMP signaling, signal compartmentalization, and regulation of second messenger dynamics.
PDE4A is expressed in multiple tissues and cell types, with particularly important roles in immune cells, neuronal tissues, and inflammatory environments. Its expression pattern reflects the widespread reliance on cAMP signaling for regulation of immune responses, neurotransmission, and cellular homeostasis. PDE4A often functions as part of multiprotein signaling assemblies, allowing precise local control of cAMP levels.
From a disease-relevance perspective, Phosphodiesterase 4A has been investigated in inflammatory disorders, neuropsychiatric conditions, and cancer. Dysregulated PDE4A activity can lead to abnormal cAMP signaling, contributing to altered immune activation, impaired neuronal signaling, and changes in cell proliferation. As a result, PDE4A and related family members are considered important targets in studies of inflammation and signal transduction.
At the molecular level, Phosphodiesterase 4A contains conserved catalytic domains responsible for cAMP hydrolysis, along with regulatory regions that mediate protein-protein interactions and subcellular targeting. Alternative splicing and post-translational regulation can influence its apparent behavior in biochemical assays without altering the primary amino acid sequence. PDE4A antibody reagents support research applications focused on second messenger signaling and disease-associated alterations in cAMP regulation, with NSJ Bioreagents providing reagents intended for research use. -
UniProt
- P27815
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途径
- cAMP Metabolic Process
抗原
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