MECP2 抗体 (AA 119-453)
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北京 101111
Quick Overview for MECP2 抗体 (AA 119-453) (ABIN8093317)
抗原
See all MECP2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 119-453
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原理
- MECP2 Antibody / Methyl-CpG-binding protein 2
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human MECP2 recombinant protein (Position: K119-R453) was used as the immunogen for Methyl-CpG-binding protein 2 antibody.
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亚型
- IgG
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anti-Methyl CpG Binding Protein 2 (MECP2) (AA 7-148) antibody
MECP2 适用: 人 WB, IHC, ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 8H4A5B9 unconjugated
anti-Methyl CpG Binding Protein 2 (MECP2) (pSer423) antibodyMECP2 适用: 人, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB29261 unconjugated
anti-Methyl CpG Binding Protein 2 (MECP2) (AA 81-170) antibodyMECP2 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 1B11 unconjugated
anti-Methyl CpG Binding Protein 2 (MECP2) (AA 400-428) antibodyMECP2 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB25959 unconjugated
anti-Methyl CpG Binding Protein 2 (MECP2) (AA 1-486) antibodyMECP2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Methyl CpG Binding Protein 2 (MECP2) (AA 58-87), (N-Term) antibodyMECP2 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB27934 unconjugated
anti-Methyl CpG Binding Protein 2 (MECP2) (pSer80) antibodyMECP2 适用: 人 DB 宿主: 兔 Polyclonal RB27934 unconjugated
anti-Methyl CpG Binding Protein 2 (MECP2) (AA 1-30), (N-Term) antibodyMECP2 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB2387 unconjugated
anti-Methyl CpG Binding Protein 2 (MECP2) (AA 399-428), (C-Term) antibodyMECP2 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB2386 unconjugated
anti-Methyl CpG Binding Protein 2 (MECP2) (AA 81-170) antibodyMECP2 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 4B6 unconjugated
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应用备注
- Optimal dilution of the Methyl-CpG-binding protein 2 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the Methyl-CpG-binding protein 2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- MECP2 (Methyl CpG Binding Protein 2 (MECP2))
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别名
- MECP2
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背景
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Methyl-CpG-binding protein 2 antibody targets Methyl-CpG-binding protein 2, encoded by the MECP2 gene. Methyl-CpG-binding protein 2 is a nuclear chromatin-associated protein that binds methylated CpG dinucleotides and functions as a regulator of gene expression. MECP2 plays a central role in interpreting DNA methylation marks and linking epigenetic modifications to transcriptional control.
Functionally, Methyl-CpG-binding protein 2 acts primarily as a transcriptional regulator by recruiting corepressor complexes and chromatin-modifying enzymes to methylated DNA regions. Through these interactions, MECP2 influences chromatin structure and gene accessibility, contributing to long-term regulation of gene expression rather than rapid transcriptional switching. A MECP2 antibody supports studies focused on epigenetic regulation, chromatin biology, and transcriptional repression mechanisms.
MECP2 expression is particularly prominent in neuronal cells, where it is required for normal brain development and synaptic function. Subcellular localization is predominantly nuclear, consistent with its role in chromatin binding, although distribution within the nucleus can vary depending on chromatin state and developmental context. MECP2 abundance and activity are tightly regulated, reflecting its importance in maintaining transcriptional homeostasis.
From a disease-relevance perspective, mutations or altered regulation of MECP2 are strongly associated with neurodevelopmental disorders, most notably Rett syndrome. Dysregulation of MECP2-dependent gene expression programs can disrupt neuronal maturation and function, highlighting the protein's critical role in nervous system development and maintenance. MECP2 has also been investigated in broader contexts of epigenetic dysfunction and transcriptional misregulation.
At the molecular level, Methyl-CpG-binding protein 2 contains a methyl-CpG-binding domain responsible for recognizing methylated DNA, along with transcriptional repression domains that mediate protein-protein interactions. Isoform variation and post-translational regulation can influence MECP2 behavior in experimental systems without altering its core DNA-binding function. MECP2 antibody reagents support research applications focused on epigenetic control and nuclear gene regulation, with NSJ Bioreagents providing reagents intended for research use. -
UniProt
- P51608
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途径
- Inositol Metabolic Process, Chromatin Binding, Synaptic Membrane
抗原
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