GPX4 抗体 (AA 30-197)
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北京 101111
Quick Overview for GPX4 抗体 (AA 30-197) (ABIN8093215)
抗原
See all GPX4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 30-197
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原理
- GPX4 Antibody / Glutathione Peroxidase 4
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纯化方法
- Antigen affinity
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免疫原
- Amino acids A30-F197 of human Glutathione Peroxidase 4 were used as the immunogen for the GPX4 antibody.
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亚型
- IgG
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anti-Glutathione Peroxidase 4 (GPX4) (AA 30-197) antibody
GPX4 适用: 人 WB, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Glutathione Peroxidase 4 (GPX4) (AA 74-197) antibodyGPX4 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Glutathione Peroxidase 4 (GPX4) (AA 74-197) antibodyGPX4 适用: 小鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Glutathione Peroxidase 4 (GPX4) antibodyKD Validated GPX4 适用: 人 WB, FACS, IF (p) 宿主: 兔 Monoclonal 25GB2980 unconjugated Recombinant Antibody
anti-Glutathione Peroxidase 4 (GPX4) (C-Term) antibodyVerified GPX4 适用: 人 WB, IHC, ELISA, IP 宿主: 山羊 Polyclonal unconjugated
anti-Glutathione Peroxidase 4 (GPX4) (C-Term) antibodyGPX4 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Glutathione Peroxidase 4 (GPX4) antibodyGPX4 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Glutathione Peroxidase 4 (GPX4) antibodyGPX4 适用: 人, 小鼠, 大鼠 IHC, IF, ELISA, FACS 宿主: 小鼠 Monoclonal LHM 2 unconjugated
anti-Glutathione Peroxidase 4 (GPX4) (AA 72-121) antibodyGPX4 适用: 人, 小鼠, 大鼠, 猴, 斑马鱼, 豚鼠, Cow, 山羊 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Glutathione Peroxidase 4 (GPX4) (AA 81-93) antibodyGPX4 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the GPX4 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the GPX4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- GPX4 (Glutathione Peroxidase 4 (GPX4))
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别名
- GPX4
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背景
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GPX4 Antibody targets Glutathione Peroxidase 4, a selenium-dependent antioxidant enzyme encoded by the GPX4 gene that plays a critical role in protecting cells from oxidative damage. Glutathione Peroxidase 4 belongs to the glutathione peroxidase family and is unique among its members due to its ability to directly reduce lipid hydroperoxides within biological membranes. Through this activity, GPX4 contributes to maintenance of membrane integrity and cellular redox balance.
Functionally, Glutathione Peroxidase 4 catalyzes the reduction of phospholipid hydroperoxides and cholesterol hydroperoxides using glutathione as a reducing agent. This activity distinguishes GPX4 from other glutathione peroxidases that primarily act on soluble peroxide substrates. By limiting lipid peroxidation, GPX4 prevents oxidative damage to cellular membranes and associated macromolecules. A GPX4 Antibody enables investigation of antioxidant defense mechanisms and lipid redox regulation in research studies focused on cellular stress responses.
GPX4 expression is observed in many tissues, reflecting its importance in fundamental cellular protection mechanisms. At the subcellular level, Glutathione Peroxidase 4 is found in multiple compartments, including the cytoplasm, nucleus, and mitochondria, depending on isoform and cellular context. This broad distribution allows GPX4 to protect diverse cellular structures from oxidative injury. Changes in GPX4 expression or localization may indicate altered redox state, metabolic stress, or activation of cell death pathways.
At the molecular level, GPX4 contains a conserved catalytic site that incorporates the amino acid selenocysteine, which is essential for its peroxidase activity. This structural feature confers high reactivity toward lipid hydroperoxides and enables efficient detoxification of oxidized lipids. Regulation of GPX4 expression and activity occurs at transcriptional and post-translational levels and is influenced by cellular selenium availability and redox conditions.
From a biological and disease relevance perspective, GPX4 has been extensively studied in the context of ferroptosis, a regulated form of cell death driven by lipid peroxidation. Loss or inhibition of GPX4 activity leads to accumulation of lipid peroxides and subsequent membrane damage, triggering ferroptotic cell death. As a result, GPX4 is a central focus of research into oxidative stress, neurodegeneration, cancer biology, and metabolic disease, where redox imbalance plays a pathogenic role.
GPX4 Antibody reagents are valuable tools for studying antioxidant enzyme function, lipid peroxidation control, and redox-dependent cell death pathways. These antibodies support research into oxidative stress responses, ferroptosis regulation, and disease-associated alterations in cellular antioxidant defenses. NSJ Bioreagents provides GPX4 Antibody products intended for research use. -
UniProt
- P36969
抗原
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