DCLK1 抗体 (AA 1-728)
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Quick Overview for DCLK1 抗体 (AA 1-728) (ABIN8093134)
抗原
See all DCLK1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-728
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原理
- DCLK1 Antibody / Doublecortin-like kinase 1
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human DCLK1 recombinant protein (amino acids M1-S728) was used as the immunogen for the Doublecortin-like kinase 1 antibody.
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亚型
- IgG
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anti-Doublecortin-Like Kinase 1 (DCLK1) (AA 390-647) antibody
DCLK1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Doublecortin-Like Kinase 1 (DCLK1) (AA 690-720) antibodyDCLK1 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal RB3161 unconjugated
anti-Doublecortin-Like Kinase 1 (DCLK1) (AA 640-729) antibodyDCLK1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 6H4 unconjugated
anti-Doublecortin-Like Kinase 1 (DCLK1) (AA 143-381) antibodyDCLK1 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Doublecortin-Like Kinase 1 (DCLK1) antibodyKD Validated DCLK1 适用: 人 WB, FACS 宿主: 兔 Monoclonal 24GB4805 unconjugated Recombinant Antibody
anti-Doublecortin-Like Kinase 1 (DCLK1) (AA 1-30), (N-Term) antibodyDCLK1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB3059 unconjugated
anti-Doublecortin-Like Kinase 1 (DCLK1) antibodyDCLK1 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-Doublecortin-Like Kinase 1 (DCLK1) (AA 390-647) antibodyDCLK1 适用: 人 WB, IHC 宿主: 小鼠 Monoclonal C8 unconjugated
anti-Doublecortin-Like Kinase 1 (DCLK1) antibodyDCLK1 适用: 人, 小鼠 WB 宿主: 小鼠 Monoclonal 1751CT665-1-72 unconjugated
anti-Doublecortin-Like Kinase 1 (DCLK1) (AA 685-712) antibodyDCLK1 适用: 人 WB 宿主: 兔 Polyclonal RB40386 unconjugated
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应用备注
- Optimal dilution of the Doublecortin-like kinase 1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the Doublecortin-like kinase 1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- DCLK1 (Doublecortin-Like Kinase 1 (DCLK1))
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别名
- DCLK1
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背景
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Doublecortin-like kinase 1 antibody targets Doublecortin-like kinase 1, encoded by the DCLK1 gene. Doublecortin-like kinase 1 is a cytoplasmic serine-threonine kinase that combines microtubule-binding domains with a C-terminal kinase region, enabling coordination between cytoskeletal organization and intracellular signaling. Originally characterized in neuronal systems, DCLK1 is now recognized for its broader role in epithelial biology and cellular plasticity.
Functionally, Doublecortin-like kinase 1 contributes to regulation of cell morphology, migration, and differentiation by modulating microtubule stability and kinase-dependent signaling pathways. Through these combined activities, DCLK1 supports dynamic changes in cellular structure and behavior. A Doublecortin-like kinase 1 antibody supports studies focused on cytoskeletal signaling, cell fate regulation, and kinase-driven cellular processes.
DCLK1 expression is restricted to specific cell populations rather than being ubiquitous. In epithelial tissues, DCLK1 is frequently associated with rare cells exhibiting progenitor-like or regenerative characteristics. Its cytoplasmic localization and selective expression pattern have made DCLK1 a widely used marker in studies examining cellular heterogeneity and tissue renewal mechanisms.
From a disease-relevance perspective, Doublecortin-like kinase 1 has been extensively investigated in cancer research. Elevated DCLK1 expression has been linked to tumor initiation, progression, and resistance to therapy in multiple cancer types, particularly within the gastrointestinal tract. These findings have positioned DCLK1 as a biomarker of tumor-associated cell populations and a protein of interest for studies of cancer cell plasticity and signaling.
At the molecular level, Doublecortin-like kinase 1 contains conserved domains that regulate both microtubule interaction and kinase activity. Alternative splicing and post-translational regulation can influence its functional behavior and apparent migration in biochemical assays without altering the primary amino acid sequence. Doublecortin-like kinase 1 antibody reagents support research applications focused on cancer biology, progenitor cell regulation, and microtubule-associated kinase function, with NSJ Bioreagents providing reagents intended for research use. -
UniProt
- O15075
抗原
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