Recombinant CD3D 抗体 (C-Term)
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Quick Overview for Recombinant CD3D 抗体 (C-Term) (ABIN8093064)
抗原
See all CD3D 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- C-Term
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原理
- CD3 delta Antibody / CD3D
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免疫原
- A recombinant fragment corresponding to the C-terminus of human CD3D (exact sequence is proprietary) was used as the immuongen for the CD3D/CD3 delta subunit antibody.
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亚型
- IgG, kappa
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anti-CD3d Molecule, delta (CD3-TCR Complex) (CD3D) (AA 127-171) antibody
CD3D 适用: 人 ICC, FACS, ELISA 宿主: 小鼠 Monoclonal 6B6B12 unconjugated
anti-CD3d Molecule, delta (CD3-TCR Complex) (CD3D) (AA 127-171) antibodyCD3D 适用: 人 WB, FACS, ELISA 宿主: 小鼠 Monoclonal 4B9G9 unconjugated
anti-CD3d Molecule, delta (CD3-TCR Complex) (CD3D) (AA 22-105) antibodyCD3D 适用: 人 FACS, ELISA 宿主: 小鼠 Monoclonal 1F6A8 unconjugated
anti-CD3d Molecule, delta (CD3-TCR Complex) (CD3D) (AA 127-171) antibodyCD3D 适用: 人 ELISA 宿主: 小鼠 Monoclonal 1H12G5 unconjugated
anti-CD3d Molecule, delta (CD3-TCR Complex) (CD3D) (AA 22-105) antibodyCD3D 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-CD3d Molecule, delta (CD3-TCR Complex) (CD3D) (AA 18-113) antibodyCD3D 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-CD3d Molecule, delta (CD3-TCR Complex) (CD3D) (AA 1-171) antibodyCD3D 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-CD3d Molecule, delta (CD3-TCR Complex) (CD3D) (Internal Region) antibodyCD3D 适用: 人, 大鼠, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-CD3d Molecule, delta (CD3-TCR Complex) (CD3D) antibodyCD3D 适用: 人, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-CD3d Molecule, delta (CD3-TCR Complex) (CD3D) (AA 22-106) antibodyCD3D 适用: 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the CD3D/CD3 delta subunit antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.05 % BSA, 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- CD3D/CD3 delta subunit antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.
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- CD3D (CD3d Molecule, delta (CD3-TCR Complex) (CD3D))
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别名
- CD3 delta
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背景
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CD3D antibody recognizes CD3 delta subunit, a type I transmembrane protein encoded by the CD3D gene and commonly referred to as CD3 delta chain. CD3 delta is an essential component of the T cell receptor CD3 complex, which mediates antigen recognition and intracellular signaling in T lymphocytes. As part of the multi-subunit TCR-CD3 complex, CD3 delta contributes to assembly, surface expression, and signal transduction required for adaptive immune responses. CD3D antibody supports research focused on T cell biology, immune signaling, and lymphoid tissue organization.
CD3 delta associates with CD3 gamma, CD3 epsilon, and CD3 zeta chains to form the invariant signaling module of the TCR complex. Upon antigen engagement by the T cell receptor, immunoreceptor tyrosine-based activation motifs within the cytoplasmic domains of CD3 subunits become phosphorylated, initiating downstream signaling cascades that regulate T cell activation, proliferation, and cytokine production. CD3 delta is localized predominantly at the plasma membrane in mature T cells, where it stabilizes receptor expression and contributes to immune synapse formation.
In normal human tissues, CD3 delta expression is restricted to T lymphocytes within thymus, lymph node, spleen, tonsil, and peripheral blood. Within lymphoid organs, CD3 staining highlights paracortical and interfollicular T cell zones, while B cell follicles and non-lymphoid cells remain largely negative. This lineage-specific distribution makes CD3D antibody a valuable marker for identifying T cell populations in research applications. Alterations in CD3 complex expression are relevant in studies of T cell immunodeficiency and T cell malignancies, where receptor composition and signaling capacity may be affected.
Clone CD3D/13089R is a recombinant rabbit monoclonal antibody generated by defined sequence expression to support lot-to-lot consistency and reproducible performance. CD3D antibody can be used to investigate T cell receptor signaling pathways, lymphoid tissue architecture, and adaptive immune mechanisms in experimental systems. Its defined specificity and membrane-associated staining profile make it suitable for studying T cell distribution and immune system function in normal and disease-associated tissues. -
UniProt
- P04234
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途径
- TCR Signaling, CXCR4-mediated Signaling Events
抗原
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