Recombinant CEACAM6 抗体
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北京 101111
Quick Overview for Recombinant CEACAM6 抗体 (ABIN8093036)
抗原
See all CEACAM6 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- CEACAM6 Antibody / CD66c
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免疫原
- Recombinant CEACAM6 protein was used as the immunogen for the CD66c/CEACAM6 antibody.
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亚型
- IgG, kappa
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anti-Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6 (CEACAM6) antibody
CEACAM6 适用: 人 WB, ELISA, FACS, cELISA, IHC (fro) 宿主: 小鼠 Monoclonal 9A6 unconjugated
anti-Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6 (CEACAM6) antibodyCEACAM6 适用: 人 WB, IF 宿主: 兔 Monoclonal unconjugated
anti-Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6 (CEACAM6) (AA 156-265) antibodyCEACAM6 适用: 人 ELISA, IF 宿主: 小鼠 Monoclonal 1G2 unconjugated
anti-Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6 (CEACAM6) antibodyCEACAM6 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6 (CEACAM6) (AA 216-265) antibodyCEACAM6 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6 (CEACAM6) (Internal Region) antibodyCEACAM6 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6 (CEACAM6) (AA 35-320) antibodyCEACAM6 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6 (CEACAM6) antibodyCEACAM6 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB1595 unconjugated Recombinant Antibody
anti-Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6 (CEACAM6) antibody (PE)CEACAM6 适用: 人 FACS 宿主: 小鼠 Monoclonal B6-2 PE
anti-Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6 (CEACAM6) antibodyCEACAM6 适用: 人 FACS, IP 宿主: 小鼠 Monoclonal B6-2 unconjugated
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应用备注
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1. Optimal dilution of the CD66c/CEACAM6 antibody should be determined by the researcher.
2. This CD66c/CEACAM6 antibody is recombinantly produced by expression in CHO cells. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.05 % BSA, 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- CD66c/CEACAM6 antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.
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- CEACAM6 (Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6 (CEACAM6))
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别名
- CEACAM6
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背景
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CD66c antibody recognizes Carcinoembryonic antigen-related cell adhesion molecule 6, encoded by the human CEACAM6 gene. CEACAM6, also known as CD66c, NCA-90, or nonspecific cross-reacting antigen, is a glycosylphosphatidylinositol-anchored cell surface glycoprotein and a member of the carcinoembryonic antigen family within the immunoglobulin superfamily. It is predominantly localized to the plasma membrane, where it participates in cell-cell adhesion, modulation of signaling pathways, and regulation of epithelial architecture. CD66c antibody is widely used to study epithelial differentiation and tumor-associated antigen expression in a variety of tissues.
CEACAM6 is physiologically expressed in granulocytes and in epithelial cells of the gastrointestinal tract, pancreas, and biliary system. In normal tissues, expression is typically restricted to the apical surface of epithelial cells, reflecting its role in luminal cell interactions and barrier function. Functionally, CEACAM6 contributes to intercellular adhesion and can influence intracellular signaling cascades that regulate proliferation, survival, and migration. Its overexpression has been associated with enhanced resistance to apoptosis and altered integrin-mediated signaling, supporting tumor cell survival and metastatic potential.
In oncology research, CD66c antibody is frequently applied to evaluate CEACAM6 upregulation in colorectal carcinoma, pancreatic adenocarcinoma, gastric carcinoma, lung adenocarcinoma, and other epithelial malignancies. Increased CEACAM6 expression has been correlated with tumor progression, invasion, and poor clinical outcome in several studies. Because CEACAM6 is a surface glycoprotein with limited expression in most non-epithelial tissues, it serves as a useful marker for epithelial-derived tumors and for distinguishing specific carcinoma subtypes in diagnostic pathology research.
Clone CEACAM6/13372R is a recombinant rabbit monoclonal antibody designed to detect CD66c expression in research applications. As a recombinant monoclonal antibody, it is produced by expression of a defined antibody sequence in cultured cells, providing batch-to-batch consistency and high specificity. A CD66c antibody such as clone CEACAM6/13372R is suitable for detecting CEACAM6 protein in immunohistochemistry, western blot, and other laboratory assays, enabling detailed investigation of epithelial biology and tumor-associated antigen expression. -
UniProt
- P40199
抗原
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