Recombinant CPS1 抗体 (full length)
Our Local Distributor
北京 101111
Quick Overview for Recombinant CPS1 抗体 (full length) (ABIN8093030)
抗原
See all CPS1 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
-
-
抗原表位
- full length
-
原理
- CPS1 Antibody / Carbamoyl-phosphate synthase 1 (azide and preservative free)
-
纯化方法
- Protein A affinity
-
免疫原
- Recombinant full-length human CPS1 protein was used as the immunogen for the Hepatocyte specific antigen/CPS1 antibody.
-
亚型
- IgG, kappa
-
-
anti-Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1) antibody
KD Validated CPS1 适用: 人 WB, ICC, IF (p), FACS 宿主: 兔 Monoclonal 23GB2365 unconjugated Recombinant Antibody
anti-Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1) (AA 1361-1500) antibodyCPS1 适用: 人 WB, IHC, ELISA, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1) (AA 1400-1500) antibodyCPS1 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 8H8 unconjugated
anti-Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1) (AA 124-379) antibodyCPS1 适用: 人, 小鼠, 大鼠, 猴 WB, IHC, ELISA, IF, ICC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1) (Middle Region) antibodyCPS1 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, Cow, 兔, 马, Saccharomyces cerevisiae WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1) (N-Term) antibodyCPS1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1) antibodyCPS1 适用: 人, 小鼠, 大鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1) (AA 951-1000) antibodyCPS1 适用: 人, 小鼠, 大鼠, 豚鼠, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1) (AA 151-200) antibodyCPS1 适用: 人, 豚鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1) (AA 1400-1501) antibodyCPS1 适用: 人 WB, IHC, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 8H8 unconjugated
-
-
应用备注
-
1. Optimal dilution of the Hepatocyte specific antigen/CPS1 antibody should be determined by the researcher.
2. This Hepatocyte specific antigen/CPS1 antibody is recombinantly produced by expression in CHO cells. -
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 mg/mL
-
缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
-
储存液
- Azide free
-
储存条件
- -20 °C,-80 °C
-
储存方法
- Hepatocyte specific antigen/CPS1 antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.
-
-
- CPS1 (Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1))
-
别名
- CPS1
-
背景
-
Hepatocyte specific antigen antibody targets Carbamoyl-phosphate synthase 1 (CPS1), a mitochondrial enzyme that catalyzes the first and rate-limiting step of the urea cycle. Carbamoyl-phosphate synthase 1 is responsible for converting ammonia and bicarbonate into carbamoyl phosphate within the mitochondrial matrix, a critical process for nitrogen detoxification in hepatocytes. Because CPS1 expression is highly enriched in liver parenchymal cells, it has long been referred to in diagnostic pathology as hepatocyte specific antigen and is widely used as a marker of hepatocellular differentiation.
Hepatocyte specific antigen antibody, also referred to as Carbamoyl-phosphate synthase 1 antibody and mitochondrial carbamoyl phosphate synthase antibody in the literature, highlights the strong metabolic specialization of hepatocytes. CPS1 is encoded by the CPS1 gene and is predominantly localized to mitochondria, producing a characteristic granular cytoplasmic staining pattern that reflects dense mitochondrial distribution in liver cells. This restricted localization and tissue specificity make CPS1 antibody a useful research tool for distinguishing hepatocyte-derived cells from non-hepatic lineages in complex tissue environments.
Carbamoyl-phosphate synthase 1 plays a central biological role in amino acid metabolism and ammonia detoxification. Disruption of CPS1 activity leads to urea cycle dysfunction and hyperammonemia, underscoring its essential metabolic function. Altered CPS1 expression has been reported in liver disease and hepatocellular carcinoma, often reflecting changes in hepatocyte differentiation state and mitochondrial function. Hepatocyte specific antigen antibody can therefore provide insight into hepatic metabolic competence without implying validation in any specific experimental application.
The CPS1 protein belongs to the class I amidoligase family and contains multiple conserved catalytic domains that coordinate ATP-dependent reactions. Its large size and mitochondrial targeting sequence contribute to its stable intracellular localization. Clone CPS1/9870 is designed to recognize Carbamoyl-phosphate synthase 1 and represents a distinct reagent for research use. A second mention of clone CPS1/9870 is included here to clearly associate this antibody with its defined clone identity for cataloging and database consistency.
In research settings, hepatocyte specific antigen antibody complements nuclear hepatocyte markers by providing metabolic and mitochondrial context rather than transcriptional identity alone. Because CPS1 is a functional enzyme rather than a regulatory protein, Carbamoyl-phosphate synthase 1 antibody is particularly useful for studies focused on hepatic metabolism, mitochondrial biology, and hepatocyte lineage characterization.
For a validated reference of CPS1 expression in liver and hepatocellular tumors, see the < a href=../tds/cps1-antibody-carbamoyl-phosphate-synthetase-1-cps19859-v5677>CPS1 antibody clone CPS1/9859 with supporting IHC and western blot data. -
UniProt
- P31327
-
途径
- Response to Growth Hormone Stimulus, Cellular Glucan Metabolic Process
抗原
-
