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Recombinant ACE2 抗体 (AA 705-805)

Name: Recombinant ACE2 抗体 (AA 705-805)
SKU: ABIN8093005
Availability: OutOfStock

This 兔单克隆 antibody specifically detects ACE2 in IHC. It exhibits reactivity toward 人.

产品编号 ABIN8093005

发货至: 中国

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Quick Overview for Recombinant ACE2 抗体 (AA 705-805) (ABIN8093005)

抗原

See all ACE2 抗体

ACE2 (Angiotensin I Converting Enzyme 2 (ACE2))

抗体类型

Recombinant Antibody

适用

人

宿主

兔

克隆类型

单克隆

标记

This ACE2 antibody is un-conjugated

应用范围

Immunohistochemistry (IHC)

克隆位点

MSVA-919R

Discover our top product ACE2 Primary Antibody

抗原表位
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9

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AA 705-805

原理

ACE2 Antibody / Angiotensin-converting enzyme 2

免疫原

A recombinant fragment (around amino acids 705-805) of human ACE2 (exact sequence is proprietary) was used as the immunogen for the ACE2 Antibody for IHC / Angiotensin-Converting Enzyme 2 Antibody for IHC.

亚型

IgG, kappa
anti-Angiotensin I Converting Enzyme 2 (ACE2) (AA 601-700) antibody
ACE2 适用: 人 WB, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Angiotensin I Converting Enzyme 2 (ACE2) (AA 18-250) antibody
ACE2 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Angiotensin I Converting Enzyme 2 (ACE2) antibody
ACE2 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal AC18F unconjugated

anti-Angiotensin I Converting Enzyme 2 (ACE2) (AA 773-805), (C-Term) antibody
ACE2 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB4819 unconjugated

anti-Angiotensin I Converting Enzyme 2 (ACE2) (AA 392-739) antibody
ACE2 适用: 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Angiotensin I Converting Enzyme 2 (ACE2) (AA 93-464) antibody
ACE2 适用: 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Angiotensin I Converting Enzyme 2 (ACE2) (N-Term) antibody
Verified ACE2 适用: 人 WB, IHC, ELISA, FACS 宿主: 山羊 Polyclonal unconjugated

anti-Angiotensin I Converting Enzyme 2 (ACE2) (AA 351-450) antibody
KO Validated ACE2 适用: 人, 小鼠 WB, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Angiotensin I Converting Enzyme 2 (ACE2) (AA 140-172) antibody
ACE2 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB4815-4816 unconjugated

anti-Angiotensin I Converting Enzyme 2 (ACE2) (AA 59-90), (N-Term) antibody
ACE2 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB4811-4812 unconjugated

应用备注

1. Optimal dilution of the ACE2 Antibody for IHC / Angiotensin-Converting Enzyme 2 Immunohistochemistry Antibody should be determined by the researcher.

2. This ACE2/Angiotensin-converting enzyme 2 antibody is recombinantly produced by expression in CHO cells.

3. Manual Protocol: Freshly cut sections should be used (less than 10 days between cutting and staining). Heat-induced antigen retrieval for 5 minutes in an autoclave at 121oC in pH 7.8 Target Retrieval Solution buffer. Apply the antibody at a dilution of 1:150 at 37oC for 60 minutes. Visualization of bound antibody by the EnVision Kit (Dako, Agilent) according to the manufacturer's directions.

限制

仅限研究用
状态

Liquid

缓冲液

Antibody in 1X PBS with 0.05 % BSA, 0.05 % sodium azide

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C,-80 °C

储存方法

ACE2/Angiotensin-converting enzyme 2 antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.
抗原

ACE2 (Angiotensin I Converting Enzyme 2 (ACE2))

别名

ACE2

背景

Angiotensin-converting enzyme 2 (ACE2) is a membrane-associated metalloprotease encoded by the ACE2 gene that functions as a key regulator of the renin-angiotensin system. ACE2 Antibody for IHC is used to visualize the tissue distribution and cellular localization of Angiotensin-converting enzyme 2 within formalin-fixed paraffin-embedded specimens using immunohistochemistry. ACE2, also referred to as ACE2 receptor or Angiotensin-converting enzyme homolog, is widely expressed in epithelial tissues where it participates in the enzymatic conversion of angiotensin II to angiotensin-(1-7), a signaling pathway associated with vasodilatory and anti-inflammatory effects. Because of its physiological importance in cardiovascular, pulmonary, and epithelial biology, ACE2 expression patterns have been extensively studied in histological tissue sections.

Immunohistochemistry studies commonly show ACE2 staining in epithelial cells of several organs including intestine, kidney, lung, and glandular tissues. Within these tissues, ACE2 protein is typically detected along cell membranes and within the cytoplasm of epithelial cells, consistent with its role as a membrane-associated enzyme involved in peptide processing and receptor-mediated signaling. Visualization of ACE2 expression in histological sections allows researchers to examine epithelial distribution patterns while preserving tissue architecture, enabling comparison of expression between different organs and between normal and disease-associated tissues.

Large-scale immunohistochemistry studies frequently utilize human tissue microarray (TMA) platforms to evaluate ACE2 expression across diverse tissues in a standardized format. In human tissue microarray panels containing multiple normal and cancer tissues, ACE2 staining is typically strongest in epithelial compartments while stromal and connective tissues often display minimal signal. This epithelial-biased staining pattern has been consistently reported in public expression datasets and immunohistochemistry studies, supporting the use of tissue microarrays as an efficient method for assessing ACE2 distribution across many tissue types within a single experiment.

A recombinant rabbit monoclonal antibody, clone MSVA-919R, recognizes ACE2 protein and is suitable for immunohistochemical analysis of ACE2 expression in human tissues. When applied to FFPE tissue sections and human tissue microarray (TMA) panels, this ACE2 Antibody for IHC highlights epithelial cell populations in multiple organs, enabling visualization of ACE2-positive cells within their histological context. These staining patterns align with published ACE2 expression profiles and with large-scale protein expression datasets such as the Human Protein Atlas, supporting the use of immunohistochemistry for studying ACE2 tissue distribution and epithelial expression patterns in normal and cancer tissues.

This antibody is also part of a broader collection of < a href='/ihc-antibodies-tissue-microarray-validated.html'>IHC antibodies validated by tissue microarray analysis, supporting consistent staining across normal and cancer tissues.

UniProt

Q9BYF1

途径

ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour