Recombinant CD166 抗体 (full length)
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Quick Overview for Recombinant CD166 抗体 (full length) (ABIN8092994)
抗原
See all CD166 (ALCAM) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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抗原表位
- full length
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原理
- ALCAM Antibody / Activated leukocyte cell adhesion molecule (azide and preservative free)
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免疫原
- Recombinant full-length human CD166 protein was used as the immunogen for the ALCAM/Activated leukocyte cell adhesion molecule antibody.
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亚型
- IgG2b, kappa
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anti-Activated Leukocyte Cell Adhesion Molecule (ALCAM) (AA 48-216) antibody
ALCAM 适用: 人 IHC, FACS, ELISA, ICC 宿主: 小鼠 Monoclonal 8E12C7 unconjugated
anti-Activated Leukocyte Cell Adhesion Molecule (ALCAM) (AA 48-216) antibodyALCAM 适用: 人, 小鼠 WB, IHC, FACS, ELISA 宿主: 小鼠 Monoclonal 4H9A5 unconjugated
anti-Activated Leukocyte Cell Adhesion Molecule (ALCAM) (AA 227-381) antibodyALCAM 适用: 人 WB, IHC, FACS, ELISA 宿主: 小鼠 Monoclonal 2F1B12 unconjugated
anti-Activated Leukocyte Cell Adhesion Molecule (ALCAM) (AA 405-524) antibodyALCAM 适用: 人 WB, IHC, ELISA 宿主: 小鼠 Monoclonal 5B3 unconjugated
anti-Activated Leukocyte Cell Adhesion Molecule (ALCAM) (AA 167-406) antibodyALCAM 适用: 人, 大鼠, 小鼠 WB, IHC, FACS, IF 宿主: 兔 Polyclonal unconjugated
anti-Activated Leukocyte Cell Adhesion Molecule (ALCAM) antibodyKD Validated ALCAM 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB3405 unconjugated Recombinant Antibody
anti-Activated Leukocyte Cell Adhesion Molecule (ALCAM) (AA 58-87) antibodyALCAM 适用: 人 WB, IHC, FACS, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Activated Leukocyte Cell Adhesion Molecule (ALCAM) (AA 28-527) antibodyALCAM 适用: 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Activated Leukocyte Cell Adhesion Molecule (ALCAM) (AA 58-87), (N-Term) antibodyALCAM 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB19989 unconjugated
anti-Activated Leukocyte Cell Adhesion Molecule (ALCAM) (AA 28-527) antibodyALCAM 适用: 人 IHC 宿主: 小鼠 Monoclonal 5-2# unconjugated
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应用备注
- Optimal dilution of the ALCAM/Activated leukocyte cell adhesion molecule antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- ALCAM/Activated leukocyte cell adhesion molecule antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.
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- CD166 (ALCAM) (Activated Leukocyte Cell Adhesion Molecule (ALCAM))
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别名
- ALCAM
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背景
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ALCAM antibody targets Activated leukocyte cell adhesion molecule, a type I transmembrane glycoprotein belonging to the immunoglobulin superfamily that mediates cell-cell adhesion through homophilic and heterophilic interactions. ALCAM is also widely known in the literature as CD166 and MEMD, and functions as an adhesion receptor involved in maintaining tissue architecture and regulating intercellular communication. The protein is primarily localized to the cell membrane, where it participates in stable cell-cell contacts and dynamic adhesive interactions in both immune and non-immune tissues.
Activated leukocyte cell adhesion molecule plays a critical role in immune cell trafficking, synapse formation, and leukocyte-endothelial interactions. Through its extracellular immunoglobulin-like domains, ALCAM mediates adhesion between activated leukocytes and other cell types, facilitating immune surveillance and inflammatory responses. In addition to immune contexts, ALCAM contributes to epithelial organization, neuronal development, and stem cell niche maintenance, reflecting its broad functional relevance across multiple biological systems.
ALCAM expression is observed in a variety of tissues, including hematopoietic cells, endothelial cells, epithelial cells, and neural tissues. At the cellular level, ALCAM antibody staining is typically membranous, consistent with its function as a surface adhesion molecule, although cytoplasmic staining may be observed depending on cellular context and protein turnover. The regulated expression of ALCAM is essential for balancing adhesive stability with cellular motility during development and tissue remodeling.
In cancer biology, ALCAM has been implicated in tumor progression, invasion, and metastasis, with expression levels and localization patterns varying across tumor types. Altered ALCAM-mediated adhesion can influence tumor cell cohesion, interactions with the tumor microenvironment, and metastatic dissemination. As a result, ALCAM expression has been explored as a marker of tumor differentiation, invasive potential, and cell adhesion status in several malignancies.
This ALCAM antibody is suitable for research applications aimed at detecting Activated leukocyte cell adhesion molecule expression and localization in cells and tissue sections. Clone rALCAM/9811 is designed to recognize ALCAM and supports investigation of cell adhesion mechanisms, immune cell interactions, and adhesion-related changes associated with disease states. Use of this antibody enables detailed study of CD166-associated signaling and structural functions in physiological and pathological models. -
UniProt
- Q13740
抗原
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