DAXX 抗体 (pSer495) (Biotin)
Quick Overview for DAXX 抗体 (pSer495) (Biotin) (ABIN757674)
抗原
See all DAXX 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer495
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特异性
- This phosphorylation site is homologous to that of Ser505 in Bovine.
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交叉反应
- 人, 大鼠
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预测反应
- Cow,Pig
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic phosphopeptide derived from human DAXX around the phosphorylation site of Ser495
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亚型
- IgG
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应用备注
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WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C for 12 months.
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有效期
- 12 months
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- DAXX (Death-Domain Associated Protein (DAXX))
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别名
- DAXX
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背景
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Synonyms: DAP6, EAP1, BING2, Death domain-associated protein 6, Daxx, hDaxx, ETS1-associated protein 1, Fas death domain-associated protein
Background: This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]
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基因ID
- 1616
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UniProt
- Q9UER7
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途径
- Intracellular Steroid Hormone Receptor Signaling Pathway
抗原
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