FCN3 抗体
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Quick Overview for FCN3 抗体 (ABIN8065465)
抗原
See all FCN3 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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原理
- Anti-H-Ficolin Antibody
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特异性
- ABIN8065465 reacts specifically with H-ficolin. No cross-reaction has been observed with L- or M-ficolin.
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预测反应
- Human
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纯化方法
- Protein A or Protein G purified
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免疫原
- Recombinant human H-ficolin
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亚型
- IgG1, kappa
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anti-Ficolin (Collagen/fibrinogen Domain Containing) 3 (Hakata Antigen) (FCN3) (AA 214-243), (C-Term) antibody
FCN3 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB31101 unconjugated
anti-Ficolin (Collagen/fibrinogen Domain Containing) 3 (Hakata Antigen) (FCN3) (AA 1-288) antibodyFCN3 适用: 人 WB, IP 宿主: 小鼠 Monoclonal 4B4 unconjugated
anti-Ficolin (Collagen/fibrinogen Domain Containing) 3 (Hakata Antigen) (FCN3) (AA 34-297) antibodyFCN3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Ficolin (Collagen/fibrinogen Domain Containing) 3 (Hakata Antigen) (FCN3) (AA 35-84) antibodyFCN3 适用: 人, 马, Bat, 小鸡, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Ficolin (Collagen/fibrinogen Domain Containing) 3 (Hakata Antigen) (FCN3) (N-Term) antibodyFCN3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Ficolin (Collagen/fibrinogen Domain Containing) 3 (Hakata Antigen) (FCN3) (AA 1-288) antibodyFCN3 适用: 人 ELISA, WB 宿主: 小鼠 Polyclonal unconjugated
anti-Ficolin (Collagen/fibrinogen Domain Containing) 3 (Hakata Antigen) (FCN3) (AA 1-288) antibodyFCN3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Ficolin (Collagen/fibrinogen Domain Containing) 3 (Hakata Antigen) (FCN3) (AA 213-243), (C-Term) antibodyFCN3 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 0.01 M phosphate buffer, pH 7.4, with 0.5 M NaCl and 15 mM sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- 2-8°C without exposure to light
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有效期
- 24 months
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- FCN3 (Ficolin (Collagen/fibrinogen Domain Containing) 3 (Hakata Antigen) (FCN3))
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别名
- H-Ficolin
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背景
- FCN3, FCNH, HAKA1, ficolin-3, H-ficolin, collagen/fibrinogen domain-containing lectin 3 p35, collagen/fibrinogen domain-containing protein 3, ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen),Calcium-dependent lectin, which acts as a pattern recognition receptor that initiates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:11907111, PubMed:15804047, PubMed:17215869, PubMed:26133042). Specifically recognizes and binds carbohydrates on the pathogen surface, activating the MASP1 serine protease and initiating the proteolytic cascade of the lectin complement pathway (PubMed:15804047, PubMed:17215869, PubMed:26133042). Specifically binds N-Acetylglucosamine (GlcNAc,) GalNAc (N-acetylgalactosamine) and D-fucose on the surface of pathogens, as well as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and S.minnesota (PubMed:17215869). {ECO:0000269|PubMed:11907111, ECO:0000269|PubMed:15804047, ECO:0000269|PubMed:17215869, ECO:0000269|PubMed:26133042}.,FCN3,H-Ficolin (Hakata antigen, Ficolin-3) is an innate immunity pattern recognition molecule found in human serum. H-Ficolin binds to distinct pathogen-associated molecular patterns (PAMP) formed by carbohydrates (GlcNAc, GalNAc and fucose) activating complement through the lectin pathway by means of the associated MASPs ((MBL)-associated serine proteases). H-Ficolin consists of 35 kDa protein chains associated in triplet subunits which are again associated in high molecular weight oligomers by means of disulfide bonds at the N-terminal region.
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分子量
- 35 kDa
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基因ID
- 8547
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UniProt
- O75636
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途径
- Complement System
抗原
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