FCN1 抗体 (AA 95-314)
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Quick Overview for FCN1 抗体 (AA 95-314) (ABIN8065464)
抗原
See all FCN1 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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抗原表位
- AA 95-314
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原理
- Anti-M-Ficolin Antibody
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特异性
- ABS 036-05 reacts specifically with M-Ficolin.
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预测反应
- Human
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纯化方法
- Protein A or Protein G purified
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免疫原
- Recombinant human M-Ficolin (aa 95 to 314)
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亚型
- IgG1, kappa
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anti-Ficolin (Collagen/fibrinogen Domain Containing) 1 (FCN1) (AA 30-326) antibody
FCN1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Ficolin (Collagen/fibrinogen Domain Containing) 1 (FCN1) (AA 25-279) antibodyFCN1 适用: 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ficolin (Collagen/fibrinogen Domain Containing) 1 (FCN1) (AA 25-317) antibodyFCN1 适用: 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ficolin (Collagen/fibrinogen Domain Containing) 1 (FCN1) (AA 201-300) antibodyFCN1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2B7 unconjugated
anti-Ficolin (Collagen/fibrinogen Domain Containing) 1 (FCN1) (AA 30-326) antibodyFCN1 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Ficolin (Collagen/fibrinogen Domain Containing) 1 (FCN1) (AA 45-249) antibodyFCN1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Ficolin (Collagen/fibrinogen Domain Containing) 1 (FCN1) (AA 1-326) antibodyFCN1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Ficolin (Collagen/fibrinogen Domain Containing) 1 (FCN1) (AA 1-326) antibodyFCN1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Ficolin (Collagen/fibrinogen Domain Containing) 1 (FCN1) (AA 239-267), (C-Term) antibodyFCN1 适用: 人 WB 宿主: 兔 Polyclonal RB36809 unconjugated
anti-Ficolin (Collagen/fibrinogen Domain Containing) 1 (FCN1) (AA 215-264) antibodyFCN1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 0.01 M phosphate buffer, pH 7.4, with 0.5 M NaCl and 15 mM sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- 2-8°C without exposure to light
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有效期
- 24 months
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- FCN1 (Ficolin (Collagen/fibrinogen Domain Containing) 1 (FCN1))
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别名
- M-Ficolin
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背景
- FCN1, FCNM, ficolin-1, M-ficolin, ficolin (collagen/fibrinogen domain-containing) 1, ficolin-A, ficolin-alpha,Extracellular lectin, which acts as a pattern recognition receptor that initiates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:16116205, PubMed:17897951, PubMed:20032467). Specifically recognizes and binds carbohydrates on the pathogen surface, activating the MASP1 serine protease and initiating the proteolytic cascade of the lectin complement pathway (PubMed:16116205, PubMed:20032467). Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage (PubMed:20032467, PubMed:20400674). May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8 (PubMed:21037097). {ECO:0000269|PubMed:16116205, ECO:0000269|PubMed:17897951, ECO:0000269|PubMed:20032467, ECO:0000269|PubMed:20400674, ECO:0000269|PubMed:21037097}.,FCN1,M-Ficolin (Ficolin-1) is a non-serum protein that is expressed in leukocytes and lung. M-Ficolin precipitates with mannose-binding lectin (MBL)-associated serine proteases (MASP)-1 and MASP-2, indicating that M-Ficolin forms complexes with MASP-1 and MASP-2, recognizes certain types of bacteria and subsequently activates the lectin pathway.
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分子量
- 35 kDa
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基因ID
- 2219
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UniProt
- O00602
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途径
- Complement System
抗原
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