C9 抗体
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北京 101111
Quick Overview for C9 抗体 (ABIN8065437)
抗原
See all C9 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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原理
- Anti-Complement C9 Antibody
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特异性
- ABS 004-22 is specific for complement factor C9.
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预测反应
- Human
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纯化方法
- Protein A or Protein G purified
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免疫原
- Complement factor C9
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亚型
- IgG1, kappa
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anti-Complement Component C9 (C9) (AA 191-220), (Center) antibody
C9 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB33918 unconjugated
anti-Complement Component C9 (C9) (AA 22-265) antibodyC9 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Complement Component C9 (C9) (AA 136-512) antibodyC9 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Complement Component C9 (C9) (Internal Region) antibodyC9 适用: 人, 小鼠, 大鼠 WB, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Complement Component C9 (C9) (AA 139-519) antibody (APC)C9 适用: 兔 WB, IHC 宿主: 豚鼠 Polyclonal APC
anti-Complement Component C9 (C9) (AA 191-220) antibodyC9 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Complement Component C9 (C9) (AA 336-554) antibodyC9 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Complement Component C9 (C9) (AA 205-216) antibodyVerified C9 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Complement Component C9 (C9) (AA 289-515) antibodyC9 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Complement Component C9 (C9) (AA 184-411) antibodyC9 适用: 人 WB, ICC, IHC (p), IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 0.01 M phosphate buffer, pH 7.4, with 0.5 M NaCl and 15 mM sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- 2-8°C without exposure to light
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有效期
- 24 months
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- C9 (Complement Component C9 (C9))
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别名
- Complement C9
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背景
- C9, ARMD15, C9D, complement component C9, complement component 9,Pore-forming component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis (PubMed:22832194, PubMed:26841837, PubMed:26841934, PubMed:27052168, PubMed:30552328, PubMed:6177822, PubMed:9212048, PubMed:9634479). The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways (PubMed:39914456, PubMed:39814882, PubMed:9212048, PubMed:9634479). The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:9212048, PubMed:9634479). Constitutes the pore-forming subunit of the MAC complex: during MAC assembly, C9 associates with the C5b8 intermediate complex, and polymerizes to complete the pore (PubMed:26841934, PubMed:30111885, PubMed:30552328, PubMed:34752492, PubMed:4055801, PubMed:6177822). {ECO:0000269|PubMed:22832194, ECO:0000269|PubMed:26841837, ECO:0000269|PubMed:26841934, ECO:0000269|PubMed:27052168, ECO:0000269|PubMed:30111885, ECO:0000269|PubMed:30552328, ECO:0000269|PubMed:34752492, ECO:0000269|PubMed:39814882, ECO:0000269|PubMed:39914456, ECO:0000269|PubMed:4055801, ECO:0000269|PubMed:6177822, ECO:0000269|PubMed:9212048, ECO:0000269|PubMed:9634479}.,C9,Complement factor C9 is a 71 kDa single-chain ellipsoid a-globular molecule of 558 amino acids including a leader sequence of 20 amino acids. C9 bind the C5b8 complex on membranes and has an unique property in forming tubular structures containing between 12 and 18 monomers, closely resembling the membrane attack complex (MAC). The primary site of synthesis is hepatocytes, secondary sites are monocytes, fibroblasts and glial cells. The normal level of C9 in plasma is 60 μg/mL, and the level is up regulated from hepatocytes by IFN-?.
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分子量
- 71 kDa
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基因ID
- 735
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UniProt
- P02748
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途径
- Complement System
抗原
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