C5 抗体
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北京 101111
Quick Overview for C5 抗体 (ABIN8065435)
抗原
See all C5 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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原理
- Anti-Complement C5a/C5a(desArg) Anaphylatoxin Antibody
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特异性
- ABIN8065435 binds to a neoepitope exposed on C5a/C5a(desArg).
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预测反应
- Human,Non-Human Primate
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纯化方法
- Protein A or Protein G purified
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免疫原
- Purified human C5a
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亚型
- IgG1, kappa
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anti-Complement Component 5 (C5) (N-Term) antibody
C5 适用: 大鼠, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 5 (C5) (AA 701-755) antibodyC5 适用: 小鼠 WB, IF (p), IF (cc), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 5 (C5) (AA 253-281), (N-Term) antibodyC5 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB21866 unconjugated
anti-Complement Component 5 (C5) (AA 253-281) antibodyC5 适用: 人 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 5 (C5) (C-Term) antibodyC5 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 5 (C5) (AA 1-77) antibodyC5 适用: 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 5 (C5) (AA 253-281), (N-Term) antibodyC5 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 0.01 M phosphate buffer, pH 7.4, with 0.5 M NaCl and 15 mM sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- 2-8°C without exposure to light
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有效期
- 24 months
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- C5 (Complement Component 5 (C5))
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别名
- Complement C5a/C5a
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背景
- C5, C5D, C5a, C5b, CPAMD4, ECLZB, complement C5, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4, C5a anaphylatoxin, anaphylatoxin C5a analog, complement component 5, prepro-C5,Precursor of the C5a anaphylatoxin and complement C5b components of the complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:12878586, PubMed:18204047, PubMed:30643019, PubMed:6554279). Activated downstream of classical, alternative, lectin and GZMK complement pathways (PubMed:12878586, PubMed:18204047, PubMed:30643019, PubMed:39914456, PubMed:39814882, PubMed:6554279). {ECO:0000269|PubMed:12878586, ECO:0000269|PubMed:18204047, ECO:0000269|PubMed:30643019, ECO:0000269|PubMed:39814882, ECO:0000269|PubMed:39914456, ECO:0000269|PubMed:6554279}., [Complement C5b]: Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis (PubMed:26841837, PubMed:27052168, PubMed:30552328, PubMed:30643019). Complement C5b is generated following cleavage by C5 convertase and initiates formation of the MAC complex: C5b binds sequentially C6, C7, C8 and multiple copies of the pore-forming subunit C9 (PubMed:30552328, PubMed:30643019). During MAC complex assembly, the C5b6 subcomplex, composed of complement C5b and C6, associates with the outer leaflet of target cell membrane, reducing the energy for membrane bending (PubMed:30552328, PubMed:32569291). {ECO:0000269|PubMed:26841837, ECO:0000269|PubMed:27052168, ECO:0000269|PubMed:30552328, ECO:0000269|PubMed:30643019, ECO:0000269|PubMed:32569291}., [C5a anaphylatoxin]: Mediator of local inflammatory process released following cleavage by C5 convertase (PubMed:8182049, PubMed:9553099). Acts by binding to its receptor (C5AR1 or C5AR2), activating G protein-coupled receptor signaling and inducing a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes (PubMed:36806352, PubMed:37852260, PubMed:37169960, PubMed:8182049, PubMed:9553099). C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation (PubMed:342601, PubMed:37852260, PubMed:37169960, PubMed:5765461, PubMed:8182049, PubMed:9553099). {ECO:0000269|PubMed:342601, ECO:0000269|PubMed:36806352, ECO:0000269|PubMed:37169960, ECO:0000269|PubMed:37852260, ECO:0000269|PubMed:5765461, ECO:0000269|PubMed:8182049, ECO:0000269|PubMed:9553099}.,C5,Complement C5a is generated in the circulation by the activation of complement. It is a so-called anaphylatoxin of 74 amino-acid residues generated by the action of C5 convertase, which cleaves C5 into C5a and C5b. It is rapidly inactivated by serum carboxypeptidase B, which removes the C-terminal arginine residue generating C5a(desArg).
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分子量
- 188 kDA (Presursor C5), 9 kDa (C5a and C5a(desArg))
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基因ID
- 727
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UniProt
- P01031
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途径
- Complement System, Carbohydrate Homeostasis
抗原
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