GLI1 抗体 (AA 800-1057) (PE)
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北京 101111
Quick Overview for GLI1 抗体 (AA 800-1057) (PE) (ABIN8055281)
抗原
See all GLI1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 800-1057
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原理
- Anti-GLI1 Antibody PE Conjugated
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预测反应
- Human GLI1 shares 79.8% amino acid (aa) sequence identity with mouse GLI1.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human GLI1 recombinant protein (Position: Y800-Q1057). Human GLI1 shares 79.8% amino acid (aa) sequence identity with mouse GLI1.
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亚型
- IgG
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应用备注
- Flow Cytometry, Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
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有效期
- 12 months
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- GLI1 (Zinc Finger Protein GLI1 (GLI1))
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别名
- GLI1
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背景
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Background: GLI1, also known as GLI, is a protein originally isolated in human glioblastoma. The protein is encoded by GLI1 gene. It is mapped to 12q13.3. This gene is a member of a select group of cellular genes that are genetically altered in primary human tumors. GLI1 encodes a member of the GLI-Kruppel family of zinc finger proteins in the final steps of Hedgehog signaling in normal development and disease. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Beside, various upstream patterning signals may be integrated by the Gli proteins to a coherent programme of neurogenesis.
Gene Full Name: GLI family zinc finger 1
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基因ID
- 2735
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UniProt
- P08151
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途径
- Hedgehog Signaling, Dopaminergic Neurogenesis
抗原
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