TFEB 抗体 (AA 50-461) (Fluoro594)
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北京 101111
Quick Overview for TFEB 抗体 (AA 50-461) (Fluoro594) (ABIN8047945)
抗原
See all TFEB 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 50-461
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原理
- Anti-TFEB Antibody Fluoro594 Conjugated
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human TFEB recombinant protein (Position: T50-A461).
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亚型
- IgG
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anti-Transcription Factor EB (TFEB) (AA 1-476) antibody
TFEB 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal S1 unconjugated
anti-Transcription Factor EB (TFEB) (AA 214-326) antibodyTFEB 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, FACS, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Transcription Factor EB (TFEB) (C-Term) antibodyTFEB 适用: 人, 小鼠 WB, FACS, IP 宿主: 兔 Monoclonal BLR070G unconjugated Recombinant Antibody
anti-Transcription Factor EB (TFEB) (AA 1-476) antibodyTFEB 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Transcription Factor EB (TFEB) (Middle Region) antibodyTFEB 适用: 人, Cow, 犬, 马, 山羊, 兔 WB 宿主: 兔 Polyclonal unconjugated
anti-Transcription Factor EB (TFEB) (AA 10-90) antibodyTFEB 适用: 人, 小鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Transcription Factor EB (TFEB) (AA 1-220) antibodyTFEB 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Transcription Factor EB (TFEB) (AA 426-476) antibodyTFEB 适用: 人, 小鼠 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Transcription Factor EB (TFEB) antibodyTFEB 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB4750 unconjugated Recombinant Antibody
anti-Transcription Factor EB (TFEB) (N-Term) antibodyTFEB 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Flow Cytometry, Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
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有效期
- 12 months
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- TFEB (Transcription Factor EB (TFEB))
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别名
- TFEB
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背景
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Background: Transcription factor EB is a protein that in humans is encoded by the TFEB gene. TFEB is a master gene for lysosomal biogenesis. It encodes a transcription factor that coordinates expression of lysosomal hydrolases, membrane proteins and genes involved in autophagy. Upon nutrient depletion and under aberrant lysosomal storage conditions such as in lysosomal storage diseases, TFEB translocates from the cytoplasm to the nucleus, resulting in the activation of its target genes. TFEB overexpression in cultured cells induces lysosomal biogenesis, exocytosis and autophagy. Viral-mediated TFEB overexpression in cellular and mouse models of lysosomal storage disorders and in common neurodegenerative diseases such as Huntington, Parkinson and Alzheimer diseases, resulted in intracellular clearance of accumulating molecules and rescue of disease phenotypes. TFEB is activated by PGC1-alpha and promotes reduction of htt aggregation and neurotoxicity in a mouse model of Huntington disease. TFEB overexpression has been found in patients with renal cell carcinoma and pancreatic cancer and was shown to promote tumorogenesis via induction of varius oncogenic signals.
Gene Full Name: transcription factor EB
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基因ID
- 7942
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UniProt
- P19484
抗原
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