SHBG 抗体 (AA 30-210) (Fluoro550)
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Quick Overview for SHBG 抗体 (AA 30-210) (Fluoro550) (ABIN8036824)
抗原
See all SHBG 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 30-210
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原理
- Anti-Sex Hormone Binding Globulin/SHBG Antibody Fluoro550 Conjugated
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特异性
- No cross reactivity with other proteins.
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交叉反应 (详细)
- No cross-reactivity with other proteins
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预测反应
- Human SHBG shares 72% amino acid (aa) sequence identity with both mouse,rat SHBG.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human SHBG recombinant protein (Position: L30-A210). Human SHBG shares 72% amino acid (aa) sequence identity with both mouse and rat SHBG.
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亚型
- IgG
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应用备注
- Flow Cytometry, Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
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有效期
- 12 months
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- SHBG (Sex Hormone Binding Globulin (SHBG))
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别名
- SHBG
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背景
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Background: Sex hormone-binding globulin (SHBG) is a glycoprotein that binds to the sex hormones,androgen and estrogen. SHBG is produced mostly by the liver and is released into the bloodstream. Other sites that produce SHBG include the brain, uterus, testes, and placenta. SHBG has both enhancing and inhibiting hormonal influences. It decreases with high levels of insulin, growth hormone, insulin-like growth factor 1 (IGF-1), androgens, prolactin and transcortin. High estrogen, andthyroxine cause it to increase. It has been found that the monosaccharides glucose and fructose reduced human SHBG production by hepatocytes, irrespective of the presence of insulin, by downregulation of hepatocyte nuclear factor-4A and replacement of HNF4A by COUP-TFI at a cis-element within the human SHBG promoter, coincident with repression of its transcriptional activity.
Gene Full Name: sex hormone binding globulin
Sequence Similarities: Contains 2 laminin G-like domains.
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基因ID
- 6462
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UniProt
- P04278
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途径
- Hormone Transport
抗原
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