BRIP1
适用: 人, 小鼠
WB, IF (p), IF (cc)
宿主: 兔
Polyclonal
AbBy Fluor® 594
应用备注
IF(IHC-P)(1:100-500) Optimal working dilution should be determined by the investigator.
限制
仅限研究用
状态
Liquid
缓冲液
0.01M PBS, pH 7.4 with 10 mg/ml BSA
储存液
Sodium azide
注意事项
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件
-20 °C
抗原
BRIP1
(BRCA1 Interacting Protein C-terminal Helicase 1 (BRIP1))
别名
BACH1/BRIP1
背景
BACH1 is a member of the DEAH helicase family that interacts with BRCA1 in vivo. BACH1 is a DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. BACH1 acts late in the Fanconi anemia pathway after FANCD2 ubiquitination and is involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1. The BACH1/BRCA1 complex formation contributes to a key function of BRCA1. Therefore it is likely that BACH1 is a target of germline cancer-inducing mutations. Synonym: BACH 1, BRIP1, BACH-1, BRAC 1 Associated C Terminal Helicase 1, BRCA 1 Interacting Protein 1, BRCA1 binding helicase like protein BACH1, BRCA1 interacting protein C terminal helicase 1, BRIP 1, BRIP-1, FANCJ, ATP dependent RNA helicase BRIP1, Fanconi anemia group J protein, FLJ90232, MGC126521, MGC126523, OF antibody Protein FACJ.