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PTPN12 抗体 (AA 276-311) (HRP)

The 兔 多克隆 anti-PTPN12 antibody is suitable to detect PTPN12 in samples from 人. It has been validated for WB, ELISA 和 IHC.
产品编号 ABIN8028324
发货至: 中国
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Quick Overview for PTPN12 抗体 (AA 276-311) (HRP) (ABIN8028324)

抗原

See all PTPN12 抗体
PTPN12 (Protein Tyrosine Phosphatase G1 (PTPN12))

适用

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  • 1
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宿主

  • 64
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克隆类型

  • 64
  • 6
多克隆

标记

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This PTPN12 antibody is conjugated to HRP

应用范围

  • 50
  • 17
  • 14
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Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
  • 抗原表位

    • 15
    • 11
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
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    AA 276-311

    原理

    Anti-PTPN12 Antibody HRP Conjugated

    交叉反应 (详细)

    No cross-reactivity with other proteins.

    纯化方法

    Immunogen affinity purified.

    免疫原

    E.coli-derived human PTPN12 recombinant protein (Position: A276-D311).

    亚型

    IgG
  • 应用备注

    Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

    储存条件

    -20 °C

    储存方法

    At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

    有效期

    12 months
  • 抗原

    PTPN12 (Protein Tyrosine Phosphatase G1 (PTPN12))

    别名

    PTPN12

    背景

    Background: Tyrosine-protein phosphatase non-receptor type 12 is an enzyme that in humans is encoded by the PTPN12 gene. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

    Gene Full Name: protein tyrosine phosphatase non-receptor type 12

    基因ID

    5782

    UniProt

    Q05209
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