PGC 抗体 (AA 145-356) (PE)
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Quick Overview for PGC 抗体 (AA 145-356) (PE) (ABIN8020081)
抗原
See all PGC 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 145-356
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原理
- Anti-PGC Antibody PE Conjugated
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交叉反应 (详细)
- No cross reactivity with other proteins.
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预测反应
- Human PGC shares 69.5%,70% amino acid (aa) sequence identity with mouse,rat PGC,respectively.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human PGC recombinant protein (Position: Y145-N356). Human PGC shares 69.5% and 70% amino acid (aa) sequence identity with mouse and rat PGC, respectively.
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亚型
- IgG
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应用备注
- Flow Cytometry, Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
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有效期
- 12 months
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- PGC (Pepsinogen C (PGC))
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别名
- PGC
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背景
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Background: Progastricsin also known as pepsinogen C or pepsinogen II is a pepsinogen precursor of the enzyme gastricsin that in humans is encoded by the PGC gene. This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1.
Gene Full Name: progastricsin
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基因ID
- 5225
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UniProt
- P20142
抗原
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