PRKACG 抗体 (AA 251-351)
Quick Overview for PRKACG 抗体 (AA 251-351) (ABIN751813)
抗原
See all PRKACG 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 251-351
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预测反应
- Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Chicken
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human PKA gamma
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亚型
- IgG
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应用备注
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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- PRKACG (Protein Kinase, CAMP-Dependent, Catalytic, gamma (PRKACG))
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别名
- PKA gamma
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背景
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Synonyms: KAPG, PKA C gamma, PRKACG, Protein kinase cAMP dependent catalytic gamma, Serine threonine protein kinase, KAPCG_HUMAN.
Background: PKA (or cAPK) is a cyclic AMP dependent protein kinase. When activated by the second messenger cAMP, PKA mediates diverse cellular mechanisms, including proliferation, ion transport, regulation of metabolism, plus gene transcription. PKA is comprised of two dimers of two subunits, R (regulatory) and C (catalytic). Two families of R subunit (RI and RII) and three C subunit isoforms (C alpha, C beta, and C gamma) have been identified each possessing distinct cAMP binding properties and resulting in different phosphorylation states. C subunit is activated through autophosphorylation and direct phosphorylation at Thr197 by PDK-1. Tissue specific expression of C gamma, indicates pressure on C gamma during evolution, acting to modulate it in a functionally specific way. Certain amino acid substitutions make C gamma a distinct member of the cAMP dependent subfamily of protein kinases, and suggest that C gamma may be distinct in its protein substrate specificity or its interaction with the different regulatory subunits.
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基因ID
- 5568
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途径
- AMPK Signaling, Hedgehog Signaling, Thyroid Hormone Synthesis, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Lipid Metabolism
抗原
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