TIMP2 抗体 (AA 27-220) (Biotin)
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Quick Overview for TIMP2 抗体 (AA 27-220) (Biotin) (ABIN8009342)
抗原
See all TIMP2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 27-220
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原理
- Anti-TIMP2 Antibody Biotin Conjugated
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特异性
- No cross reactivity with other proteins.
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交叉反应 (详细)
- No cross-reactivity with other proteins
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预测反应
- coli-derived human TIMP2 recombinant protein (Position: C27-P220). Human TIMP2 shares 98.5% amino acid (aa) sequence identity with both mouse,rat TIMP2.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E. coli-derived human TIMP2 recombinant protein (Position: C27-P220). Human TIMP2 shares 98.5% amino acid (aa) sequence identity with both mouse and rat TIMP2.
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亚型
- IgG
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应用备注
- Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.
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有效期
- 12 months
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- TIMP2 (Metalloproteinase Inhibitor 2 (TIMP2))
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别名
- TIMP2
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背景
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Background: TIMP metallopeptidase inhibitor 2, a tissue inhibitor of metalloproteinases, also known as TIMP2, is a human gene, thought to be a metastasis suppressor. This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to ly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.
Gene Full Name: TIMP metallopeptidase inhibitor 2
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基因ID
- 7077
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UniProt
- P16035
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途径
- cAMP Metabolic Process
抗原
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