LAT 抗体 (AA 28-235) (PE)
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Quick Overview for LAT 抗体 (AA 28-235) (PE) (ABIN8006237)
抗原
See all LAT 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 28-235
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原理
- Anti-LAT Antibody PE Conjugated
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交叉反应 (详细)
- No cross reactivity with other proteins.
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预测反应
- Human LAT shares 61%,59.3% amino acid (aa) sequence identity with mouse,rat LAT,respectively.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human LAT recombinant protein (Position: H28-E235). Human LAT shares 61% and 59.3% amino acid (aa) sequence identity with mouse and rat LAT, respectively.
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亚型
- IgG
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应用备注
- Flow Cytometry, Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
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有效期
- 12 months
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- LAT (Linker For Activation of T Cells (LAT))
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别名
- LAT
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背景
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Background: The Linker for activation of T cells, also known as linker of activated T cells or LAT, is a protein involved in the T-cell antigen receptor signal transduction pathway which in humans is encoded by the LAT gene. The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms.
Gene Full Name: linker for activation of T cells
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基因ID
- 27040
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UniProt
- O43561
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途径
- TCR Signaling, Fc-epsilon Receptor Signaling Pathway
抗原
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