ITGB3BP 抗体 (AA 1-177) (FITC)
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Quick Overview for ITGB3BP 抗体 (AA 1-177) (FITC) (ABIN8000566)
抗原
See all ITGB3BP 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-177
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原理
- Anti-Centromere protein R/ITGB3BP Antibody FITC Conjugated
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交叉反应 (详细)
- No cross reactivity with other proteins.
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预测反应
- Human ITGB3BP shares 94.4%,59.8% amino acid (aa) sequence identity with mouse,rat ITGB3BP,respectively.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human Centromere protein R/ITGB3BP recombinant protein (Position: M1-N177). Human ITGB3BP shares 94.4% and 59.8% amino acid (aa) sequence identity with mouse and rat ITGB3BP, respectively.
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亚型
- IgG
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应用备注
- Flow Cytometry, Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
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有效期
- 12 months
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- ITGB3BP (Integrin beta 3 Binding Protein (Beta3-Endonexin) (ITGB3BP))
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别名
- ITGB3BP
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背景
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Background: Centromere protein R is a protein that in humans is encoded by the ITGB3BP gene. This gene encodes a transcriptional coregulator that binds to and enhances the activity of members of the nuclear receptor families, thyroid hormone receptors and retinoid X receptors. This protein also acts as a corepressor of NF-kappaB-dependent signaling. This protein induces apoptosis in breast cancer cells through a caspase 2-mediated signaling pathway. This protein is also a component of the centromere-specific histone H3 variant nucleosome associated complex (CENP-NAC) and may be involved in mitotic progression by recruiting the histone H3 variant CENP-A to the centromere. Alternate splicing results in multiple transcript variants.
Gene Full Name: integrin subunit beta 3 binding protein
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基因ID
- 23421
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UniProt
- Q13352
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途径
- Neurotrophin Signaling Pathway
抗原
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