CYLD 抗体 (AA 501-600)
Quick Overview for CYLD 抗体 (AA 501-600) (ABIN750158)
抗原
See all CYLD 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 501-600
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Cow,Horse,Chicken
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human cylindromatosis 1
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亚型
- IgG
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应用备注
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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- CYLD (Cylindromatosis (Turban Tumor Syndrome) (CYLD))
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别名
- CYLD
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背景
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Synonyms: CDMT, cylindromatosis turban tumor syndrome, cylindromatosis 1, Deubiquitinating enzyme CYLD, EAC, HSPC057, KIAA0849, turban tumor syndrome, Ubiquitin thiolesterase CYLD, Ubiquitin-specic processing protease CYLD, CYLD_HUMAN, Ubiquitin carboxyl-terminal hydrolase CYLD, CYLD, BRSS, CDMT, CYLD1, CYLDI, EAC, MFT, MFT1, SBS, TEM, USPL2.
Background: Defects in CYLD are the cause of familial cylindromatosis (CYLD) also known as turban tumor syndrome or dermal eccrine cylindromatosis. CYLD is an autosomal dominant and highly tumor type-specific disorder. The tumors (known as cylindromas because of their characteristic microscopic architecture) are believed to arise from or recapitulate the appearance of the eccrine or apocrine cells of the skin that secrete sweat and scent respectively. Cylindromas arise predominantly in hairy parts of the body with approximately 90 % on the head and neck. The development of a confluent mass which may ulcerate or become infected has led to the designation "turban tumor syndrome". The skin tumors show differentiation in the direction of hair structures, hence the synonym trichoepithelioma. CYLD has deubiquitinating activity.
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基因ID
- 1540
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途径
- Apoptosis, Activation of Innate immune Response
抗原
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