GREM1 抗体 (C-Term) (HRP)
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北京 101111
Quick Overview for GREM1 抗体 (C-Term) (HRP) (ABIN7995147)
抗原
See all GREM1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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原理
- Anti-Gremlin 1/GREM1 Antibody HRP Conjugated
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特异性
- No cross reactivity with other proteins.
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交叉反应 （详细）
- No cross-reactivity with other proteins
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预测反应
- identical to the related mouse,rat sequences.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human Gremlin 1, identical to the related mouse and rat sequences.
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亚型
- IgG
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anti-Gremlin 1 (GREM1) (AA 147-175), (C-Term) antibody
GREM1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB2060 unconjugated
anti-Gremlin 1 (GREM1) (AA 101-184) antibodyGREM1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Gremlin 1 (GREM1) (AA 26-184) antibodyGREM1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Gremlin 1 (GREM1) (AA 25-184) antibodyGREM1 适用: 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Gremlin 1 (GREM1) (AA 26-184) antibodyGREM1 适用: 人 WB, IHC 宿主: 小鼠 Monoclonal C1 unconjugated
anti-Gremlin 1 (GREM1) (AA 25-184) antibodyGREM1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Gremlin 1 (GREM1) (AA 75-184) antibodyGREM1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2D1 unconjugated
anti-Gremlin 1 (GREM1) (AA 27-184) antibodyGREM1 适用: 小鸡 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Gremlin 1 (GREM1) (AA 18-184) antibodyGREM1 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Gremlin 1 (GREM1) (AA 147-175), (C-Term) antibodyGREM1 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.
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储存条件
- -20 °C
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储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.
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有效期
- 12 months
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- GREM1 (Gremlin 1 (GREM1))
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别名
- GREM1
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背景
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Background: Gremlin, also known as Drm, is a highly conserved 20.7- kDa, 184 amino acid glycoprotein part of the DAN family and is a cysteine knot-secreted protein. Skeletal cells synthesize bone morphogenetic proteins (BMPs) and BMP antagonists. And Gremlin is expressed in osteoblasts and opposes BMP effects on osteoblastic differentiation and function in vitro. Gremlin 1 (GREM 1) is known for its antagonistic reaction with BMPs in the TGF beta signaling pathway. This gene inhibits BMP-2, BMP-4, and BMP-7. Inhibition by grem 1 of BMPs in mice allow the expression of fibroblast growth factors (FGFs) 4 and 8 and Sonic hedgehog (SHH) which are necessary for proper limb development. Gremlin 1 may play an oncogenic role especially in carcinomas of the uterine cervix, lung, ovary, kidney, breast, colon, pancreas, and sarcoma. Over-expressed gremlin 1 functions by interaction with YWHAH (Its binding site for gremlin 1 was located between residues 61-80 and gremlin 1 binding site for YWHAH was found to be located between residues 1-67). Therefore, Gremlin 1 and its binding protein YWHAH could be good targets for developing diagnostic and therapeutic strategies against human cancers.
Gene Full Name: gremlin 1, DAN family BMP antagonist
Sequence Similarities: Contains 1 HMG box DNA-binding domain.
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基因ID
- 26585
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UniProt
- O60565
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途径
- Regulation of Muscle Cell Differentiation, Tube Formation, Maintenance of Protein Location
抗原
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