PREX2 抗体 (AA 582-1094) (Biotin)
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Quick Overview for PREX2 抗体 (AA 582-1094) (Biotin) (ABIN7984898)
抗原
See all PREX2 (DEPDC2) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 582-1094
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原理
- Anti-PREX2 Antibody Biotin Conjugated
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human PREX2 recombinant protein (Position: D582-Q1094).
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亚型
- IgG
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anti-DEP Domain Containing 2 (DEPDC2) (AA 1417-1592) antibody
DEPDC2 适用: 人 ELISA, WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-DEP Domain Containing 2 (DEPDC2) (AA 1-979) antibodyDEPDC2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-DEP Domain Containing 2 (DEPDC2) (AA 582-1094) antibodyDEPDC2 适用: 人, 小鼠 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-DEP Domain Containing 2 (DEPDC2) (N-Term) antibodyDEPDC2 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, Pig, 兔, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.
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有效期
- 12 months
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- PREX2 (DEPDC2) (DEP Domain Containing 2 (DEPDC2))
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别名
- PREX2
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背景
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Background: Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 is a protein that in humans is encoded by the PREX2 gene. The protein encoded by this gene belongs to the phosphatidylinositol 3,4,5-trisphosphate (PIP3)-dependent Rac exchanger (PREX) family, which are Dbl-type guanine-nucleotide exchange factors for Rac family small G proteins. Structural domains of this protein include the catalytic diffuse B-cell lymphoma homology and pleckstrin homology (DHPH) domain, two disheveled, EGL-10, and pleckstrin homology (DEP) domains, two PDZ domains, and a C-terminal inositol polyphosphate-4 phosphatase (IP4P) domain that is found in one of the isoforms. This protein facilitates the exchange of GDP for GTP on Rac1, allowing the GTP-bound Rac1 to activate downstream effectors. Studies also show that the pleckstrin homology domain of this protein interacts with the phosphatase and tensin homolog (PTEN) gene product to inhibit PTEN phosphatase activity, thus activating the phosphoinositide-3 kinase (PI3K) signaling pathway. Conversely, the PTEN gene product has also been shown to inhibit the GEF activity of this protein. This gene plays a role in insulin-signaling pathways, and either mutations or overexpression of this gene have been observed in some cancers.
Gene Full Name: phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2
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基因ID
- 80243
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UniProt
- Q70Z35
抗原
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