CAMK2A 抗体 (AA 392-457) (HRP)
Our Local Distributor
北京 101111
Quick Overview for CAMK2A 抗体 (AA 392-457) (HRP) (ABIN7974155)
抗原
See all CAMK2A 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 392-457
-
原理
- Anti-CaMKII alpha/CAMK2A Antibody HRP Conjugated
-
特异性
- No cross reactivity with other proteins.
-
交叉反应 (详细)
- No cross-reactivity with other proteins.
-
纯化方法
- Immunogen affinity purified.
-
免疫原
- E. coli-derived human CaMKII alpha recombinant protein (Position: L392-R457).
-
亚型
- IgG
-
-
-
-
应用备注
- Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.
-
储存条件
- -20 °C
-
储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.
-
有效期
- 12 months
-
-
- CAMK2A (Calcium/calmodulin-Dependent Protein Kinase II alpha (CAMK2A))
-
别名
- CAMK2A
-
背景
-
Background: MAX (Max protein), also called Myc-associated factor x, is the most conserved dimerization component of the MYC-MAX-MXD1 network of basic helix-loop-helix leucine zipper (bHLHZ) transcription factors that regulate cell proliferation, differentiation, and apoptosis. The conservation of the MAX sequence is particularly high in the bHLHZ domain, which is involved in protein-protein interactions and DNA binding. The MAX gene is located on chromosome 14q23 by fluorescence in situ chromosomal hybridization. Both quasisymmetric heterodimers resemble the symmetric MAX homodimer, albeit with marked structural differences in the coiled-coil leucine zipper regions that explain preferential homo- and heteromeric dimerization of these 3 evolutionarily related DNA-binding proteins. MAX acts as a classic tumor suppressor gene. Normal lymphocytes from patients showed absence of methylation of the MAX promoter and biallelic expression of MAX, which ruled out an imprinting-mediated effect on MAX expression. The ability of these cells to divide, differentiate, and apoptose in the absence of Max demonstrated for the first time that these processes can occur via Max- and possibly Myc-independent mechanisms.
Gene Full Name: calcium/calmodulin dependent protein kinase II alpha
-
基因ID
- 815
-
UniProt
- Q9UQM7
-
途径
- WNT signaling, Interferon-gamma Pathway, Myometrial Relaxation and Contraction
抗原
-