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CASR 抗体 (AA 926-1078) (Biotin)

The 兔 多克隆 anti-CASR antibody is suitable to detect CASR in samples from 人, 小鼠 和 大鼠. It has been validated for WB, ELISA 和 IHC.
产品编号 ABIN7974127
发货至: 中国
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Quick Overview for CASR 抗体 (AA 926-1078) (Biotin) (ABIN7974127)

抗原

See all CASR 抗体
CASR (Calcium-Sensing Receptor (CASR))

适用

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人, 小鼠, 大鼠

宿主

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克隆类型

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多克隆

标记

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This CASR antibody is conjugated to Biotin

应用范围

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Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
  • 抗原表位

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    AA 926-1078

    原理

    Anti-Calcium Sensing Receptor/CASR Antibody Biotin Conjugated

    特异性

    No cross reactivity with other proteins.

    交叉反应 (详细)

    No cross-reactivity with other proteins

    预测反应

    coli-derived human CASR recombinant protein (Position: Q926-S1078). Human CASR shares 80.5%,78.6% amino acid (aa) sequence identity with mouse,rat CASR,respectively.

    纯化方法

    Immunogen affinity purified.

    免疫原

    E. coli-derived human CASR recombinant protein (Position: Q926-S1078). Human CASR shares 80.5% and 78.6% amino acid (aa) sequence identity with mouse and rat CASR, respectively.

    亚型

    IgG
  • 应用备注

    Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

    有效期

    12 months
  • 抗原

    CASR (Calcium-Sensing Receptor (CASR))

    别名

    CASR

    背景

    Background: The calcium-sensing receptor (CaSR) is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism.

    Gene Full Name: calcium sensing receptor

    基因ID

    846

    UniProt

    P41180

    途径

    Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis
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