TET3 抗体 (AA 976-1521)
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Quick Overview for TET3 抗体 (AA 976-1521) (ABIN7938527)
抗原
See all TET3 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 976-1521
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原理
- Tet3 antibody (mAb) (Clone 23B9), sample
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纯化方法
- Protein G Chromatography
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免疫原
- This antibody was raised against a recombinant protein corresponding amino acids 976-1521 of mouse Tet3.
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亚型
- IgG2a
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anti-Tet Methylcytosine Dioxygenase 3 (TET3) (AA 1525-1660) antibody
TET3 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Tet Methylcytosine Dioxygenase 3 (TET3) (AA 72-335) antibodyTET3 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Tet Methylcytosine Dioxygenase 3 (TET3) (AA 1-937) antibodyTET3 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Tet Methylcytosine Dioxygenase 3 (TET3) (AA 1159-1329) antibodyTET3 适用: 小鼠 WB, ChIP 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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缓冲液
- Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage
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储存条件
- -20 °C
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储存方法
- Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
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有效期
- 24 months
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- TET3 (Tet Methylcytosine Dioxygenase 3 (TET3))
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别名
- Tet3
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背景
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Background_Plain: Tet3 (Tet Methylcytosine Dioxygenase 3) is a dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming in the zygote following fertilization. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in DNA demethylation in the paternal pronucleus by mediating conversion of 5mC into 5hmC, 5fC and 5caC. Does not mediate DNA demethylation of maternal pronucleus because of the presence of DPPA3/PGC7 on maternal chromatin that prevents TET3-binding to chromatin (By similarity). In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT.
Aliases: BC037432, B430006D22Rik, D230004J03Rik
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分子量
- 180 kDa
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NCBI登录号
- NP_898961
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途径
- Warburg Effect
抗原
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