Recombinant KAT5 抗体
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北京 101111
Quick Overview for Recombinant KAT5 抗体 (ABIN7938310)
抗原
See all KAT5 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- KAT5 antibody (rAb), 100 μg (Clone 230181D5)
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纯化方法
- Protein A Chromatography
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免疫原
- This antibody was raised against the KAT5 fusion protein.
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亚型
- IgG
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应用备注
- IF: 1:200-1:800 dilution
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限制
- 仅限研究用
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缓冲液
- Purified IgG in PBS, pH 7.3, with 50 % glycerol and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage
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储存条件
- -20 °C
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储存方法
- Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
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有效期
- 24 months
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- KAT5 (K(lysine) Acetyltransferase 5 (KAT5))
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别名
- KAT5
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背景
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Background_Plain: KAT5 (K(Lysine) Acetyltransferase 5) is the atalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation.
Aliases: TIP, ESA1, PLIP, TIP60, cPLA2, HTATIP, ZC2HC5, HTATIP1
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分子量
- 60 kDa
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途径
- Intracellular Steroid Hormone Receptor Signaling Pathway
抗原
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