Histone H2A 抗体 (C-Term)
Our Local Distributor
北京 101111
Quick Overview for Histone H2A 抗体 (C-Term) (ABIN7938168)
抗原
See all Histone H2A 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
抗原表位
- C-Term
-
原理
- Histone H2Av antibody (mAb) (Clone 10E9.D1), sample
-
纯化方法
- Protein A Chromatography
-
免疫原
- This antibody was raised against a peptide in the C-terminus of the Drosophila melanogaster Histone variant H2Av.
-
亚型
- IgG2a
-
-
-
-
应用备注
- ChIP: 5 μg per ChIP WB: 0.5 - 2 μg/mL dilution
-
限制
- 仅限研究用
-
-
-
缓冲液
- Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage
-
储存条件
- -20 °C
-
储存方法
- Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
-
有效期
- 24 months
-
-
- Histone H2A
-
背景
- The nucleosome is the smallest subunit of chromatin and consists of 147 base pairs of DNA wrapped around an octamer of core histone proteins (two each of Histone H2A, Histone H2B, Histone H3 and Histone H4). Histone H2A.Z (H2AZ, H2AFZ) is a histone H2A variant, a protein similar to canonical H2A but with different molecular identity and unique functions. H2A.Z is highly conserved during evolution. It plays an important role in basic cellular mechanisms such as gene activation, chromosome segregation, heterochromatic silencing and progression through the cell cycle.In Drosophila, the H2A variant corresponding to H2AZ is H2Av. H2Av is an essential protein in Drosophila and has been implicated in both activation and repression of transcription. H2Av is localized to centromeric heterochromatin in Drosophila and flies lacking H2Av have reduced levels of heterochromatin components at the centromeres. However, H2Av nucleosome distribution throughout the rest of the Drosophila genome correlates with genes that have an open and uniform chromatin architecture at promoter regions.
-
分子量
- 15 kDa
-
NCBI登录号
- NP_524519
抗原
-