TMC6 抗体 (Cytosolic, Intracellular)
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Quick Overview for TMC6 抗体 (Cytosolic, Intracellular) (ABIN7885613)
抗原
See all TMC6 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- AA 681-695, Cytosolic, Intracellular
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原理
- A Rabbit Polyclonal Antibody to TMC6 Channel
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预测反应
- Rat,mouse - 13,14 amino acid residues are identical
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- CGPFRTLDTMYEAGR, corresponding to amino acid residues 681-695 of human TMC6
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亚型
- IgG
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anti-Transmembrane Channel-Like 6 (TMC6) (N-Term) antibody
TMC6 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:800
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7237513)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW)
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存液
- Without preservative
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- TMC6 (Transmembrane Channel-Like 6 (TMC6))
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别名
- Transmembrane channel-like protein 6
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背景
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Synonyms: Transmembrane channel-like protein 6, Epidermodysplasia verruciformis protein 1, Protein LAK-4, LAK4P, EVIN1, EV1
Description: The EVER gene belongs to a larger family of proteins referred to as the transmembrane channel-like protein (TMC) family1. The EVER1/TMC6 integral membrane protein, is located in the endoplasmic reticulum (ER) of keratinocytes, where it forms a complex with zinc transporter-1 (ZnT-1), a membrane protein responsible for zinc efflux and resistance to zinc toxicity, and thereby controlling the cellular zinc balance2. The EVER1 protein is predicted to have 10 transmembrane domains and 2 leucine zipper motifs1.The EVER1 gene encodes 2 alternatively spliced proteins, one 805 amino acids long and the other 454 amino acids, in the same open reading frame. The EVER genes are thought to be transcribed in numerous tissues including the skin1. Mutations in the TMC6 are implicated in the development of the rare autosomal recessive disease Epidermodysplasia Verruciformis (EV)3. EV is characterized by extreme susceptibility to infection by cutaneous human papillomaviruses (HPV) of the beta genus. The TMC6 genes may be involved in controlling HPV gene expression and replication in epidermal keratinocytes or they may directly affect innate and adaptive immune responses which control the clearance of HPV-infected keratinocytes in EV cases4. A recent report indicated an association between genetic variation in the TMC6 region and development of cervical cancer (CxCa)5.
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基因ID
- 11322
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UniProt
- Q7Z403
抗原
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