STX3 抗体 (Cytosolic, N-Term)
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Quick Overview for STX3 抗体 (Cytosolic, N-Term) (ABIN7885559)
抗原
See all STX3 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- AA 2-16, Cytosolic, N-Term
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原理
- A Rabbit Polyclonal Antibody to Syntaxin 3
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预测反应
- Mouse,human - identical
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- KDRLEQLKAKQLTQD(C), corresponding to amino acid residues 2-16 of rat syntaxin 3
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亚型
- IgG
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应用备注
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WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7237343)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW)
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存液
- Without preservative
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- STX3 (Syntaxin 3 (STX3))
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别名
- STX3
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背景
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Synonyms: STX3
Description: Syntaxin 3 is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) protein superfamily. The family includes 36 members in humans and is characterized by the SNARE motif, an evolutionarily conserved stretch of 60-70 amino acids that are arranged in heptad repeats1,2. SNARE proteins are involved in exocytosis and intracellular vesicle trafficking and are essential for cell growth, hormone secretion and neurotransmission, processes that require rapid, targeted, and regulated membrane fusion1,2.SNAREs can be roughly divided into vesicular (v-SNAREs) and target (t-SNAREs) based on their distribution on the transport vesicle or target membrane respectively. Thus, assembly of cognate v-/t-SNAREs between two opposing membranes generates trans-SNARE complexes, which bring the lipid bilayers in close proximity and drive membrane fusion.Syntaxin 3, like most SNAREs, is a type IV membrane protein with a relatively large N-terminus containing the SNARE motif located in the cytoplasmic side and a transmembrane domain located close to the C-terminus that functions as an anchor1,2.Syntaxin 3 functions as a plasma membrane protein t-SNARE that is involved in epithelial cell polarization. Indeed, Syntaxin 3 is specifically localized in the apical membrane of polarized epithelial cells where it likely has a role in the polarized trafficking of newly synthesized proteins3.
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基因ID
- 81802
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UniProt
- Q08849
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途径
- Synaptic Vesicle Exocytosis
抗原
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