S1PR1 抗体 (Extracellular, N-Term)
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Quick Overview for S1PR1 抗体 (Extracellular, N-Term) (ABIN7885536)
抗原
See all S1PR1 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- AA 17-30, Extracellular, N-Term
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原理
- A Rabbit Polyclonal Antibody to Sphingosine 1-Phosphate Receptor 1
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预测反应
- Mouse,rat - 13,14 amino acid residues identical
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- SDYVNYDIIVRHYN(C), corresponding to amino acid residues 17-30 of human S1PR1
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亚型
- IgG
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应用备注
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WB: 1:200
FC: 5 mg per reaction
ICC: 1:50
IHC: 1:100
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7237267)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW)
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存液
- Without preservative
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- S1PR1 (Sphingosine-1-Phosphate Receptor 1 (S1PR1))
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别名
- Sphingosine 1-phosphate receptor 1
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背景
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Synonyms: Sphingosine 1-phosphate receptor 1, S1P1, Endothelial differentiation G-protein coupled receptor 1, CD363, CHEDG1
Description: Lysophospholipids constitute a group of important lipid mediators, lysophosphatidic acid (LPA) a glycerolysophospholipid and sphingosine 1-phosphate (S1P), a lysosphingolipid. Sphingosine 1-phosphate is a bioactive lipid derived from metabolism of sphingomyelin1. Sphingosine 1-phosphate is implicated in the regulation of many cellular functions including proliferation, apoptosis, survival, adhesion, differentiation, and migration2. Sphingosine 1-phosphate exerts its activity through five distinct G-protein-coupled receptors, (also named endothelial differentiation gene receptors - EDG), S1PR1 (EDG-1), S1PR2 (EDG-5), S1PR3 (EDG-3), S1PR4 (EDG-6), and S1PR5 (EDG-8)3.Sphingosine 1-phosphate receptor 1 (S1PR1) is ubiquitously expressed. S1PR1 mRNA is detected in the brain, heart, spleen, liver, lung, thymus, kidney, skeletal muscle and lymphoid tissues4. Knockout of the gene encoding S1PR1 is lethal and therefore makes in vivo studies difficult5.
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基因ID
- 1901
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UniProt
- P21453
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途径
- Signaling Events mediated by VEGFR1 and VEGFR2
抗原
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