Sortilin 1 抗体 (Extracellular Domain)
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Quick Overview for Sortilin 1 抗体 (Extracellular Domain) (ABIN7885532)
抗原
See all Sortilin 1 (SORT1) 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- AA 320-335, Extracellular Domain
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原理
- A Rabbit Polyclonal Antibody to Sortilin
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预测反应
- Mouse,rat - identical
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- DKDTTRRIHVSTDQD(C) corresponding to amino acid residues 320-335 of human Sortilin
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亚型
- IgG
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anti-Sortilin 1 (SORT1) (AA 203-299) antibody
SORT1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1B3 unconjugated
anti-Sortilin 1 (SORT1) (AA 520-760) antibodySORT1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Sortilin 1 (SORT1) (AA 328-457) antibodySORT1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Sortilin 1 (SORT1) antibodyKD Validated SORT1 适用: 人 WB 宿主: 兔 Monoclonal 23GB4170 unconjugated Recombinant Antibody
anti-Sortilin 1 (SORT1) (AA 320-335), (Extracellular Domain) antibodyKO Validated SORT1 适用: 人 WB, IHC, FACS, IF, LCI 宿主: 兔 Polyclonal unconjugated
anti-Sortilin 1 (SORT1) (AA 731-831) antibodySORT1 适用: 人, 大鼠, 小鼠 WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Sortilin 1 (SORT1) (AA 50-320) antibodySORT1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Sortilin 1 (SORT1) (AA 203-299) antibodySORT1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Sortilin 1 (SORT1) antibodyKD Validated SORT1 适用: 人, 大鼠, 小鼠 WB, IHC 宿主: 兔 Monoclonal unconjugated Recombinant Antibody
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应用备注
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WB: 1:400
FC: 2.5 μg per reaction
ICC: The optimal concentration should be determined by the user
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7237255)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW)
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存液
- Without preservative
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- Sortilin 1 (SORT1)
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别名
- SORT1
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背景
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Synonyms: SORT1, Neurotensin receptor 3, NTR3, NT3, Glycoprotein 95, Gp95
Description: Sortilin is a member of the Vps10p family named for a yeast gene that is involved in trafficking between the trans-golgi network and the vacuole. In mammals sortilin has been shown to play an important role in golgi to endosome and golgi to lysosome trafficking. Sortilin is also known as neurotensin receptor 3 (NTS3), one of the receptors for the peptide neurotransmitter neurotensin that exerts several biological functions ranging from the regulation of dopamine transmission and pain in the central nervous system to its functioning as a local hormone affecting the gastrointestinal tract. In addition, sortilin has lately been identified as a co-receptor of p75NTR for the binding of the proneurotrophins proNGF and proBDNF. Moreover, sortilin expression was found to be essential for proNGF and proBDNF-induced neuronal cell death.Sortilin is a type I membrane protein with a large extracellular domain that includes 8 bacterial neuraminidase repeats (BNRs), a single transmembrane region and a short cytoplasmic tail. The protein is expressed in several tissues, most notably in the brain, spinal cord, skeletal muscle and adipocytes.Paradoxically for its role as either a neurotensin receptor or a p75NTR co-receptor for proneurotrophins, about 90 % of sortilin is retained in intracellular compartments with only about 10 % reaching the cell surface. It has been speculated, that changes in the cellular environment may increase cell surface expression of sortilin.
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基因ID
- 6272
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UniProt
- Q99523
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途径
- Neurotrophin Signaling Pathway
抗原
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