SSTR2 抗体 (Extracellular, N-Term)
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Quick Overview for SSTR2 抗体 (Extracellular, N-Term) (ABIN7885527)
抗原
See all SSTR2 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- AA 30-43, Extracellular, N-Term
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原理
- A Rabbit Polyclonal Antibody to Somatostatin Receptor Type 2
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预测反应
- Mouse - identical, human- 12,14 amino acid residues identical
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)GSNQTEPYYDMTSN, corresponding to amino acid residues 30-43 of rat SSTR2
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亚型
- IgG
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应用备注
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WB: 1:200
FC: 5 mg per reaction
ICC: 1:50
IHC: 1:100
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7237239)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW)
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存液
- Without preservative
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- SSTR2 (Somatostatin Receptor 2 (SSTR2))
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别名
- SSTR2
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背景
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Synonyms: SSTR2, SS2R, Smstr2, SRIF1A
Description: Somatostatin is a small cyclic peptide that is widely expressed throughout the central nervous system and peripheral tissues.1 In peripheral tissues, somatostatin exerts inhibitory effects on secretion processes, whereas in the brain, it acts as a neurotransmitter in both a stimulatory and an inhibitory manner.1,2Somatostatin mediates its action via six high affinity G-protein coupled receptors (SSTR1, SSTR2a, SSTR2b, SSTR3, SSTR4, and SSTR5), which are encoded by five genes.1,2 Expression of the different receptors is developmentally regulated in a time- and tissue-specific manner.2Somatostatin receptors have been found on a variety of neuroendocrine tumors, such as paragangliomas, carcinoids, and breast tumors.3 Synthetic peptide derivatives of somatostatin have been successfully used in the treatment of neuroendocrine malignancies and in vivo imaging of tumors that are positive for somatostatin receptors.4In general, SSTR2 is the most common SSTR subtype found in human tumors, followed by SSTR1, with SSTR3 and SSTR4 being less common.
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基因ID
- 54305
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UniProt
- P30680
抗原
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