Regulating Synaptic Membrane Exocytosis 1 (RIMS1) (AA 1039-1054), (Intracellular) 抗体
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Quick Overview for Regulating Synaptic Membrane Exocytosis 1 (RIMS1) (AA 1039-1054), (Intracellular) 抗体 (ABIN7885365)
抗原
See all Regulating Synaptic Membrane Exocytosis 1 (RIMS1) 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- AA 1039-1054, Intracellular
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原理
- A Rabbit Polyclonal Antibody to RIM1
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预测反应
- human - 14,16 amino acid residues identical,Mouse - 15
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)RAKRGRSAESLHMTSE, corresponding to amino acid residues 1039-1054 of rat RIM1
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亚型
- IgG
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anti-Regulating Synaptic Membrane Exocytosis 1 (RIMS1) (AA 596-705) antibody
KO Validated RIMS1 适用: 大鼠, 小鼠, 人, 小鸡, Frog, Hamster WB, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Regulating Synaptic Membrane Exocytosis 1 (RIMS1) (AA 207-366) antibodyKD Validated RIMS1 适用: 大鼠, 小鼠 WB, ICC 宿主: 兔 Polyclonal unconjugated
anti-Regulating Synaptic Membrane Exocytosis 1 (RIMS1) (AA 975-1025) antibodyRIMS1 适用: 小鼠, 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Regulating Synaptic Membrane Exocytosis 1 (RIMS1) (AA 955-1056) antibodyRIMS1 适用: 大鼠, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Regulating Synaptic Membrane Exocytosis 1 (RIMS1) (AA 1039-1054), (Intracellular) antibodyRIMS1 适用: 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7236714)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW)
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存液
- Without preservative
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- Regulating Synaptic Membrane Exocytosis 1 (RIMS1)
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别名
- Regulating synaptic membrane exocytosis 1
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背景
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Synonyms: Regulating synaptic membrane exocytosis 1, Rab-3-interacting molecule 1, RIMS1
Description: RIM1 is a member of the RIM superfamily of proteins (Rim1-4). These genes express seven known RIM isoforms: RIM1α, 1β, RIM2α, 2β, 2γ, and RIM3γ and RIM4γ which serve as scaffolding proteins in presynaptic nerve terminals by interacting with several other protein components localized at the active zone, including Munc13, ELKS (or CAST), liprins and voltage-gated Ca2+ channels (VGCCs). RIM1 directly binds to the C-terminal regions of the α1 subunit of N- and P/Q-type calcium channels, and can also interact with the β auxiliary subunit of P/Q-type calcium channels1-3.RIM proteins were found to be required for normal Ca2+ triggering of exocytosis. This interaction with Ca2+ channel significantly slows channel inactivation resulting in increased Ca2+ influx during action potentials.Deficiency of RIM1 decreases presynaptic Ca2+ channel density. RIM proteins are involved in neurotransmitter release and contribute to long- and short-term synaptic plasticity.
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基因ID
- 84556
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UniProt
- Q9JIR4
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途径
- Synaptic Membrane, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport, Regulation of long-term Neuronal Synaptic Plasticity
抗原
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