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Mesothelin 抗体 (Extracellular, Loop 3) (APC)

This 兔多克隆 antibody specifically detects Mesothelin in FACS 和 LCI. It exhibits reactivity toward 人, 小鼠和大鼠.

FACS

Representative domain view of the target of ABIN7885140. (Mesothelin 抗体 (Extracellular, Loop 3) (APC))

FACS

3 images

产品编号 ABIN7885140

发货至: 中国

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Quick Overview for Mesothelin 抗体 (Extracellular, Loop 3) (APC) (ABIN7885140)

抗原

See all Mesothelin (MSLN) 抗体

Mesothelin (MSLN)

适用

人, 小鼠, 大鼠

宿主

兔

克隆类型

多克隆

标记

This Mesothelin antibody is conjugated to APC

应用范围

Flow Cytometry (FACS), Live Cell Imaging (LCI)

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AA 294-307, Extracellular, Loop 3

原理

A Rabbit Polyclonal Antibody to GPER1 (extracellular) conjugated to Allophycocyanin (APC) fluorophore.

预测反应

Rat - identical, human - 13,14 amino acid residues identical.

纯化方法

Affinity purified on immobilized antigen.

免疫原

Peptide CKQSFRHAYPLTGH, corresponding to amino acid residues 294 - 307 of mouse GPER1

亚型

IgG
anti-Mesothelin (MSLN) (AA 273-407) antibody
MSLN 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 小鼠 Monoclonal MSLN-2131 unconjugated

anti-Mesothelin (MSLN) (AA 101-200) antibody
MSLN 适用: 人 WB, ELISA, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Mesothelin (MSLN) (AA 273-407) antibody
MSLN 适用: 人 IHC 宿主: 小鼠 Monoclonal MSLN-3384 unconjugated

anti-Mesothelin (MSLN) (AA 37-286) antibody
MSLN 适用: 人, 猴 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 5C11A4 unconjugated

anti-Mesothelin (MSLN) (AA 37-286) antibody
MSLN 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 4H12F8 unconjugated

anti-Mesothelin (MSLN) (AA 296-606) antibody
MSLN 适用: 人, 大鼠 WB, ELISA 宿主: 小鼠 Monoclonal 7E6A6 unconjugated

anti-Mesothelin (MSLN) (AA 37-598) antibody
MSLN 适用: 人 ELISA, IHC, IP, IF 宿主: 兔 Polyclonal unconjugated

anti-Mesothelin (MSLN) (AA 273-407) antibody (Biotin)
MSLN 适用: 人 IHC (f) 宿主: 小鼠 Monoclonal Biotin

anti-Mesothelin (MSLN) (AA 296-580) antibody
MSLN 适用: 人 ELISA, IHC, FACS 宿主: 兔 Monoclonal DM71 unconjugated

anti-Mesothelin (MSLN) antibody
MSLN 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated

应用备注

The optimal concentration should be determined by the user

说明

Negative Control: (ABIN7582043)

限制

仅限研究用
状态

Lyophilized

溶解方式

15 μL or 50 μL double distilled water (DDW), depending on the sample size.

浓度

1 mg/mL

缓冲液

PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
抗原

Mesothelin (MSLN)

别名

GPER1

背景

Synonyms: G Protein-Coupled Estrogen Receptor 1, G Protein-Coupled Receptor 30, Membrane Estrogen Receptor, Chemoattractant Receptor-Like 2, GPER
Description:
GPER1/GPR30 is an estrogen receptor belonging to the superfamily of G-protein coupled receptors (GPCRs). Like all members, GPER1 has seven membrane-spanning domains, an extracellular N-terminus and a cytoplasmic C-terminal domain. It is widely expressed in the central nervous system (CNS) and it binds 17β-estradiol (17β-E) with high affinity1.
Estrogens have long been known as important regulators of the female reproductive functions, however, is now commonly accepted that estrogens and androgens have important functions in both female and male physiology and pathology.
As opposed to the epigenetic regulatory role in estrogen signaling carried out by ER-α and ER-β estrogen receptors, signaling from GPER1 is responsible for the rapid non-genomic actions of estrogens that activate various protein-kinase cascades1. GPER1 signaling improves spatial memory, possibly via release of neurotransmitters. In addition, GPER1 activation contributes to behaviors that denote anxiety, and to social behaviors such as social memory and lordosis behavior in mice. In the male hippocampus, GPER1 activation leads to phosphorylation of the classical estrogen receptor ERα, suggesting that crosstalk with ERα is important in the manifestation of these behaviors, many of which are absent in ERα-null mice2. GPER1 activation also has several beneficial effects in the cardiovascular system including vasorelaxation, inhibition of smooth muscle cell proliferation, and protection of the myocardium against ischemia/reperfusion injury, and in the metabolic system including stimulation of insulin release and protection against pancreatic β-cell apoptosis. Thus, GPER1 is emerging as a candidate therapeutic target in both cardiovascular and metabolic diseases3.

基因ID

76854

UniProt

Q8BMP4

途径

EGFR Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Carbohydrate Homeostasis, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process