Metabotropic Glutamate Receptor 3 抗体 (Extracellular, N-Term)
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Quick Overview for Metabotropic Glutamate Receptor 3 抗体 (Extracellular, N-Term) (ABIN7885061)
抗原
See all Metabotropic Glutamate Receptor 3 (GRM3) 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- Extracellular, N-Term
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原理
- A Rabbit Polyclonal Antibody to Metabotropic Glutamate Receptor 3
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预测反应
- Mouse - identical, human,monkey - 14,15 amino residues identical
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)GDHNFMRREIKIEGD, corresponding to amino acids 24-38 of rat mGluR3
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亚型
- IgG
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anti-Glutamate Receptor, Metabotropic 3 (GRM3) (AA 433-576) antibody
GRM3 适用: 人 ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 6H10C3 unconjugated
anti-Glutamate Receptor, Metabotropic 3 (GRM3) (AA 433-576) antibodyGRM3 适用: 人 ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 7A5A6 unconjugated
anti-Glutamate Receptor, Metabotropic 3 (GRM3) (N-Term) antibodyGRM3 适用: 人, Cow, 马, 猴, Pig WB, IHC, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 3 (GRM3) (Extracellular), (N-Term) antibodyKO Validated GRM3 适用: 大鼠 WB, IHC, IF, IC, LCI 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 3 (GRM3) (N-Term) antibodyGRM3 适用: 人, 小鼠, 大鼠, Cow, 马, 猴, Hamster, Pig IHC, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 3 (GRM3) (C-Term) antibodyGRM3 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 3 (GRM3) antibodyGRM3 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 3 (GRM3) (AA 46-354) antibodyGRM3 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 3 (GRM3) (AA 828-857), (C-Term) antibodyGRM3 适用: 人 WB 宿主: 兔 Polyclonal RB4623 unconjugated
anti-Glutamate Receptor, Metabotropic 3 (GRM3) (AA 568-819) antibodyGRM3 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:600
FC: The optimal concentration should be determined by the user
ICC: 1:50
IHC: 1:100
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7235689)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW)
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存液
- Without preservative
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- Metabotropic Glutamate Receptor 3 (GRM3) (Glutamate Receptor, Metabotropic 3 (GRM3))
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别名
- Metabotropic glutamate receptor 3
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背景
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Synonyms: Metabotropic glutamate receptor 3, GRM3, mGlu3, GPRC1C
Description: L-glutamate, the major excitatory neurotransmitter in the central nervous system, operates through several receptors that are categorized as ionotropic (ligand-gated cation channels) or metabotropic (G-protein coupled receptors). The metabotropic glutamate receptor family includes eight members (mGluR1-8) that have been divided into three groups based on their sequence homology, pharmacology and signal transduction.Group II of the metabotropic glutamate receptors includes the mGluR2 and mGluR3 receptors. The receptors present the typical G-protein coupled receptor (GPCR) signature topology: seven transmembrane domains with a large extracellular N-terminus that contains the glutamate binding site, and an intracellular C-terminus.1,2 mGluR2 and mGluR3 are coupled to Gi/G0 and hence inhibit cAMP formation following receptor activation.1,2mGluR3 is expressed in neurons and glia in many brain regions including the cerebral cortex, hippocampus and brain stem. mGluR3 expression is predominantly presynaptic consistent with its role as an inhibitory autoreceptor, that is, activation of mGluR3 by glutamate inhibits additional glutamate release from the same neurons.1,2Several lines of evidence suggest that mGluR3 is important for long term depression, glial function and neuroprotection. Some studies, though not all, have shown a genetic association of mGluR3 gene polymorphisms with psychosis and with schizophrenia-related phenotypes. Based in these findings, mGluR3 has been suggested as a therapeutic target for both psychosis and schizophrenia.3
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基因ID
- 24416
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UniProt
- P31422
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途径
- cAMP Metabolic Process, Synaptic Membrane
抗原
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